Abstract Library

#1528 Medullary Thyroid Carcinoma Cell Lines – An Update

Introduction: Medullary Thyroid Carcinoma (MTC) originates from calcitonin-producing neuroendocrine C-cells of the thyroid gland. Mutations in the RET-proto-oncogene are associated with both sporadic and familial MTC. As MTC are poorly responsive to chemo- and radiation- therapy, surgery is the only curative treatment at the moment. The cytogenetics of MTC have been sparsely investigated because the cells are very difficult to cultivate. In the last three decades our research group has established 10 continues cell lines derived from primary tumor and lymph node metastasis of patients with either sporadic or hereditary MTC.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Schwach G

Authors: Schwach G, Ghaffari-Tabrizi Wizsy N, Tam-Amersdorfer C, Meier-Allard N, Siddiqui Z,

Keywords: MTC continuous cell line, characterisation, xenografts,

#1115 Cancer Stem Cells in Small Intestine Neuroendocrine Cell Line P-STS: Isolation and Molecular Characterisation

Introduction: Cancer stem cells (CSCs) represent a small subpopulation of tumour cells responsible for invasive tumour growth. Even though the presence of CSCs in neuroendocrine tumours is documented, their role in neuroendocrine tumourigenesis and metastasis is not defined as yet.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Kleinegger F, Meier-Allard N, Fuchs R, Hölzl M, Krump C,

Keywords: Cancer stem cells, tumor growth, tumorigenesis & metastasis,