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#119 Valproic acid induces apoptosis-mediated cell death of the ileal carcinoid cell line GOT1

Introduction: Downregulation of tumor suppressor genes, evasion from apoptosis, and reduced differentiation are hallmarks of cancer that can be due to abnormal epigenetic control. Histone deacetylase (HDAC) is an enzyme involved in the deacetylation of histone proteins, resulting in chromatin remodelling and altered gene transcription. HDAC inhibitors are emerging as useful anticancer drugs.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Arvidsson Y, Ahlman H, Nilsson O,

Keywords: carcinoid, HDAC, apoptosis, valproic acid,