Vitamin D Deficiency as a Risk Factor in Pancreatic Neuroendocrine Neoplasms: Report from a Series at a Single Institute

#1288

Introduction: Vitamin D deficiency (VitDdef) is hypothesized to represent a risk factor in several neoplasms. To date, vitamin D levels have not been previously evaluated in patients with pancreatic neuroendocrine neoplasms (pNENs).

Aim(s): To determine whether VitDdef may represent a risk factor for pNENs and may be associated with overall survival (OS) and progression-free survival (PFS).

Materials and methods: From September 2009 to September 2014 pNEN was newly diagnosed in 47 patients (F= 30, median age 61 yrs). Grading was G1, G2 and G3 in 32, 14 and one patient, respectively. Again, TNM stage was I, II, III and IV in 16, 17, 2 and 12 cases, respectively. Serum 25-hydroxyvitamin D (25OHvitD) levels were measured at baseline in all the patients and its deficiency was defined when facing with values <20 ng/mL. The possible association of 25OHvitD levels with PFS and OS was evaluated by the Cox proportional hazards regression. Finally, the possible correlation between 25OHvitD and disease grading and staging was also considered.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Zilli A, Fanetti I, Cavalcoli F, Conte D, Ciafardini C,

Keywords: pancreatic neuroendocrine tumor, 25OHvitamin D,