Abstract Library

#2989 Different Social Media Neuroendocrine Tumor Indexing Strategies Used by Physicians and Advocacy Groups

Introduction: The use of Twitter to disseminate medical content has increased over the last decade. Although Twitter activity by oncologists is clustered around international conferences, advocacy groups have different temporal social media patterns. Furthermore, given the non-standardized method of indexing tweets using Twitter hashtags, it can be difficult to follow the full breadth of a topic.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Meti N, Singh S,

Keywords: Neuroendocrine Tumor, Social Media, Twitter, Advocacy,

#2980 Metabolic Dysregulation and Circadian Clock in Cellular Models of Neuroendocrine Tumors

Introduction: The circadian clock genes encode transcription factors whose interaction with nuclear receptors allows the regulation of cellular metabolism.The invalidation of the genes of the clock core is associated with the development of many endocrine diseases including neuroendocrine cancer. Recently, the family of transcriptional coactivators PGC-1a has been identified as a key element in the integration of cellular metabolic state with the circadian clock. PRC, as a member of the PGC-1 family, was able to interact with several transcription factors, including the CLOCK factor. The specific induction of this PRC factor by the cell cycle, to modulate the energy function, the MAPkinase pathway and the expression of microRNAs, makes it a key factor in the metabolic adaptation of cancer cells.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Savagner F

Authors: Savagner F, Le Pennec S,

Keywords: Metabolism, Circadian clock, cell models,

#2878 Surgical Management of Neuroendocrine Tumor-Associated Liver Metastases

Introduction: Liver metastasis is common among patients who suffer from neuroendocrine tumors (NETs). Radical surgery is the standard treatment whenever possible but there is still controversies concerning the treatment strategies such as resection of the primary, role of debulking surgery, liver transplantation (LT) and neoadjuvant or adjuvant therapies.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Bengueddach A, Boudjnene N, Derriche H, Kaid M, Tabeti B,

Keywords: surgery, pancreas, liver metastasis,

#2810 Development of a Personalized Human Immunocompetent Ex-Vivo Model of Neuroendocrine Liver Metastasis Using Precision Cut Tissue Slice Technology

Introduction: Liver metastasis (LM) are very frequent (65-95%) and represent a crucial prognostic factor in patients with gastroenteropancreatic neuroendocrine neoplasms (GEP NENs). The paucity of relevant experimental models has limited the understanding of the pathophysiology of NENs and the development of efficient therapeutic strategies

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Doornebal E

Authors: Doornebal E, Harris N, Miquel R, Zen Y, Pizanias M,

Keywords: Liver, neuroendocrine liver metastasis, ex-vivo model, personalized medicine, immunocompetent, organotypic tissue slices,

#2301 Trends in Management of Gastro-Intestinal Neuroendocrine Tumors in Inflammatory Bowel Diseases: The Contribute of a Case Series.

Introduction: The risk to develop gastro-intestinal malignancies is higher in patients affected by inflammatory bowel diseases (IBD). Apart from colo-rectal cancer, related to a long standing inflammation, there is a growing evidence of neuroendocrine tumors (NETs) in these patients and a correlation between these two diseases has been postulated. We report four cases of NETs in IBD.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Rizza S

Authors: Rizza S, Canavese G, Ribaldone D, Cassoni P, Astegiano M,

Keywords: Neuroendocrine tumor, NET, inflammatory bowel disease, Chromogranin, Echo-endoscopy, EUS, IBD,