Abstract Library

#4441 Gastric neuroendocrine neoplasms in younger patients: A retrospective single-centre study

Introduction: Gastric neuroendocrine neoplasms (gNENs) are rare neoplasms arising from stomach enterochromaffin-like (ECL) cells. Type I gNENs are the most common type, typically indolent and arising in the context of chronic atrophic gastritis (CAG). While type I gNENs are generally diagnosed in pts over 50, their occurrence in younger pts raises concern about the onset of CAG-related complications at an earlier age, potentially affecting tumour growth and clinical outcomes. Young-oriented studies on type I gNETs are still lacking in literature.

Conference:

Presenting Author:

Authors: Romano E, Rinzivillo M, Marasco M, Dell' Unto E, Esposito G,

Keywords: Gastric neuroendocrine neoplasm, Young adults, Chronic Atrophic Gastritis,

#4437 Pancreatic metastases in neuroendocrine neoplasia: A systematic review

Introduction: Neuroendocrine neoplasias (NENs) are a heterogeneous group of neoplasms that often metastasise to distant organs, with the liver and bones as common targets. However, metastases to the pancreas are uncommon, accounting for 2–5% of pancreatic malignancies.

Conference:

Presenting Author:

Authors: Rinzivillo M, Romano E, Dell' Unto E, Marasco M, Panzuto F,

Keywords: pancreatic metastasis, 68Gallium-PET, incidence,

#4171 Prevalence of sarcopenia in patients with advanced intestinal neuroendocrine neoplasms at time of diagnosis

Introduction: Sarcopenia is defined as the loss of muscle mass, strength, and physical performance. First-line therapy for NENs includes somatostatin analogues (SSAs), which could be responsible for malabsorption conditions (e.g. exocrine pancreatic insufficiency - EPI), that can affect clinical outcomes and treatment response. However, the relationship between sarcopenia and NENs is still lacking in the literature.

Conference:

Presenting Author: Marasco M

Authors: Romano E, Polici M, Lerose F, Marasco M, Nardacci S,

Keywords: malnutrition, sarcopenia, somatostatin analogues, exocrine pancreatic insufficiency,

#3828 Role of endoscopic resection margin (R1) in the clinical outcome of patients with neuroendocrine neoplasia

Introduction: Endoscopic resection margin R1 (ER1) describes neoplasia presence at lateral and/or deep margin. Highest rate of R1 resection occurs in duodenal NENs (d-NENs) where advanced resection techniques [endoscopic submucosal dissection (ESD); full thickness resection (EFTR)], are more difficult to apply. In gastric (g-NENs) and rectal NENs (r-NENs), due to favourable anatomy, ESD or EFTR obtain lower rates of R1 resection.

Conference:

Presenting Author: Marasco M

Authors: Marasco M, Massironi S, Campana D, Mosca M, Dell'unto E,

Keywords: neuroendocrine, endoscopy,

#3439 Role of Radiomics in the Everolimus response prediction of metastatic neuroendocrine tumors

Introduction: Radiomics was shown to provide non-invasive imaging biomarkers predicting prognosis and treatment response.

Conference:

Presenting Author: Magi L

Authors: Magi L, Polici M, Zerunian M, Rinzivillo M, Marasco M,

Keywords: response to treatment, Everolimus, neuroendocrine tumor, Radiomics, targeted therapy,