Abstract Library

#4441 Gastric neuroendocrine neoplasms in younger patients: A retrospective single-centre study

Introduction: Gastric neuroendocrine neoplasms (gNENs) are rare neoplasms arising from stomach enterochromaffin-like (ECL) cells. Type I gNENs are the most common type, typically indolent and arising in the context of chronic atrophic gastritis (CAG). While type I gNENs are generally diagnosed in pts over 50, their occurrence in younger pts raises concern about the onset of CAG-related complications at an earlier age, potentially affecting tumour growth and clinical outcomes. Young-oriented studies on type I gNETs are still lacking in literature.

Conference:

Presenting Author:

Authors: Romano E, Rinzivillo M, Marasco M, Dell' Unto E, Esposito G,

Keywords: Gastric neuroendocrine neoplasm, Young adults, Chronic Atrophic Gastritis,

#4315 The indolent nature of type 1 gastric neuroendocrine tumours under 1cm: Insights from a dual-centre study

Introduction: Current guidelines primarily recommend endoscopic surveillance for type 1 gastric neuroendocrine tumours (g-NETs) measuring ≤10mm, though these guidelines are largely based on expert consensus rather than strong evidence.

Conference:

Presenting Author:

Authors: Dell' Unto E, Riding G, Rimondi A, Rinzivillo M, Esposito G,

Keywords: Gastric Neuroendocrine Tumour, Carcinoid, Endoscopic Surveillance,

#3686 Clinical and morphogenetic features of renal neuroendocrine tumors

Introduction: Renal neuroendocrine tumors (RenNETs) are extremely rare.

Conference:

Presenting Author: Kasajima A

Authors: Kasajima A, Pfarr N, von Werder A, Schwamborn K, Esposito I,

Keywords: Renal NET, WHO classification, Histology, immunohistochemistry, NGS,

#3506 Different patterns of recurrence after liver resection and transplantation for metastatic neuroendocrine tumors. Single center ecperience

Introduction: Liver metastases (NELM) occur in nearly half of NET pts, 80%are unresectable, and affect their prognosis. Surgery remains the most effective option; curative liver resection (LR) and liver transplantation (LT) offer the best long-term outcomes with difficult to show outcome differences due to the long course of the disease. The risk of tumor recurrence is considerable after both approaches.

Conference:

Presenting Author: Coppa J

Authors: Coppa J, Rossi R, Bongini M, Maspero M, Sposito C,

Keywords: liver metastasis, surgery, liver transplantation, recurrence,

#3505 DRD2 agonist cabergoline abolished the escape mechanism induced by mTOR inhibitor everolimus in pituitary neuroendocrine tumoral cells

Introduction: The mTOR inhibitor everolimus displays antimitotic effects on diverse neoplasms, including pituitary neuroendocrine ones (PitNETs); however, its effect is reduced by an escape mechanism that increases AKT phosphorylation (p-AKT) leading to survival pathway activation. Dopamine receptor type 2 (DRD2) reduces p-AKT in some non-functioning PitNETs (NF-PitNETs) and in lactotrophs MMQ cells, through a β-arrestin2-dependent mechanism.

Conference:

Presenting Author:

Authors: Mangili F, Esposito E, Treppiedi D, Catalano R, Marra G,

Keywords: pituitary neuroendocrine tumor, everolimus, mTOR/AKT pathway, β-arrestin 2, dopamine receptor type 2, cabergoline,