Abstract Library

#4534 Development of new 3D in vitro models for pancreatic neuroendocrine tumours (PanNETs)

Introduction: Current PanNET in vitro models struggle to accurately replicate the tumour’s biology and microenvironment, limiting understanding of the mechanisms underlying PanNET behaviour and drugs response.

Conference:

Presenting Author:

Authors: Battistella A, Pinos R, Barbaglio F, Capurso G, Schiavo Lena M,

Keywords: Preclinical models, Pan NET, microenvironment, bioprinting, tumour slices, drug testing,

#4373 Focal adhesion kinase drives proliferation and invasion in gastrointestinal neuroendocrine tumours via modulation of transformative cell signalling and gene expression

Introduction: Focal Adhesion Kinase (FAK) is a non-receptor protein kinase that localises in both the cytoplasm and nucleus, influencing cell function through its enzymatic and scaffold activities. Through its scaffold function, FAK modulates gene expression epigenetically. Gastrointestinal neuroendocrine tumours (GI-NETs) exhibit a relatively low mutation rate, supporting the hypothesis that these malignancies may be driven epigenetically. Recently, PROTAC (PROteolysis TArgeting Chimeras) technology has enabled selective inhibition and degradation of FAK, providing a novel approach to explore its role in GI-NETs.

Conference:

Presenting Author: Gagliano T

Authors: Toffoli L, Ditsiou A, Moschioni E, Hamm V, Gagliano T,

Keywords: FAK, GI-NET, Cell Signalling, Epigenetics,

#4326 An evaluation of the methodological quality of published guidelines for the surgical treatment of pulmonary carcinoids

Introduction: Leading societies have established guidelines that vary significantly regarding recommendations for surgical management of pulmonary carcinoids (PC).

Conference:

Presenting Author: Bertolaccini L

Authors: Bertolaccini L, Bardoni C, Caffarena G, Chiari M, Diotti C,

Keywords: Neuroendocrine, lung cancer, surgery, AGREE 2, methodology, guidelines,

#4325 Resection strategies for pulmonary typical carcinoids: Do surgical extents impact survival?

Introduction: While surgical resection of pulmonary typical carcinoid (TC) is primary curative treatment, optimal extent of resection remains debated, with limited data on survival outcomes and prognostic factors guiding management.

Conference:

Presenting Author: Bertolaccini L

Authors: Bertolaccini L, Caffarena G, Spada F, Pisa E, Benini L,

Keywords: neuroendocrine, lung cancer, surgery,

#3647 Autologous ECM-composed scaffolds and zebrafish PDXs for individualized theragnostic in rare neuroendocrine neoplasms

Introduction: Neuroendocrine neoplasms (NENs) are a subgroup of poorly characterized rare tumors with challenging management. Identification of clinically useful biomarkers for treatment tailoring is urgently needed.

Conference:

Presenting Author: Liverani C

Authors: Calabrese C, Miserocchi G, Vanni S, Mercatali L, de Vita A,

Keywords: NGS, zebrafish, autologous scaffold, molecular determinants,