Abstract Library

#4387 Exenatide-test for diagnosing endogenous hyperinsulinemic hypoglycaemia: A randomised placebo-controlled cross-over proof-of-principle study – FAST study

Introduction: The gold standard to diagnose endogenous hyperinsulinemic hypoglycaemia (EHH) is the fasting test which is cumbersome and incurs high costs. In the setting of radio-labelled 68Ga-exendin-4 PET/CT in patients with EHH (to localise insulinoma), we unexpectedly observed clinically relevant hypoglycaemia following administration of the tracer, which does usually not occur after GLP-1 agonist therapy in type 2 diabetic patients and in healthy subjects.

Conference:

Presenting Author: Christ E

Authors: Hepprich M, Romberg C, Fricke J, Freitag M, Mudry J,

Keywords: endogenous hyperinsulinemic hypoglycaemia, insulinoma, Exendin, Fasting test,

#4372 CVM-005: A multicentre, single-arm, phase IIa study of CVM-1118, a novel oral anti-vasculogenic mimicry (VM) agent, in patients with treatment-refractory advanced neuroendocrine tumours (NET)

Introduction: NETs are highly vascularised tumours and a viable target for anti-VM therapies. CVM-1118 is an anti-tumour agent with multiple MOAs, including disruption of VM networks and induction of apoptosis via targeting mitochondrial TRAP1 protein.

Conference:

Presenting Author: Yen C

Authors: Yen C, Chen M, Chen Y, Bai L, Chen J,

Keywords: CVM-1118, GEP-NET, anti-vasculogenic mimicry,

#3965 Nordic NEC 2: Characteristics and treatment outcome in a prospective cohort of 698 patients with high-grade digestive neuroendocrine neoplasms (NET G3 and NEC)

Introduction: Digestive high-grade (HG) neuroendocrine neoplasms (NEN) are rare with limited data on epidemiology, treatment benefit and survival.

Conference:

Presenting Author:

Authors: Sorbye H, Hjortland G, Vestermark L, Laderkarl M, Svensson J,

Keywords: NEC, NET G3, digestive, chemotherapy, neuroendocrine neoplasms,

#3789 Comparison of postoperative textbook outcome between pancreatic neuroendocrine tumor and pancreatic ductal adenocarcinoma – A nationwide retrospective cohort study

Introduction: Pancreatic neuroendocrine tumors (pNET) represent only 6% of pancreatic tumors, compared to 93% for pancreatic ductal adenocarcinoma (PDAC). Textbook outcome (TO) is a composite outcome measure that reflects a hospital’s surgical performance as well as quality of current practice.

Conference:

Presenting Author: Chen J

Authors: Chen J, Augustinus S, Engelsman A, Bonsing B, Groot Koerkamp B,

Keywords: pNET, PDAC, Dutch Pancreatic Cancer Audit, Textbook Outcome, Postoperative results,

#3719 Outcomes of surgical treatment for small bowel neuroendocrine neoplasms – The first preliminary results of the international study group for small bowel neuroendocrine neoplasm surgery registry

Introduction: Evidence for surgical treatment of small bowel neuroendocrine neoplasms (SB-NEN) often originates from single center studies. This is the first project of international study group for small bowel neuroendocrine neoplasm surgery, aiming to build and an observational registry to facilitate future research projects and randomized clinical trials.

Conference:

Presenting Author: Kaçmaz E

Authors: Kaçmaz E, Addeo P, Hennings J, Makay �, Pasquer A,

Keywords: minimally invasive surgery, laparoscopic surgery, multicenter study, international registry, small bowel NET,