Abstract Library

#4240 Plasma extracellular vesicles number and size distinguish patients with neuroendocrine neoplasms

Introduction: Neuroendocrine Neoplasms (NENs) are heterogeneous neoplasms, whose metastatic potential is challenging to predict. Extracellular vesicles (EVs) have been described as mediators of communication between the tumor cells and their microenvironment, driving the formation of metastatic niches.

Conference:

Presenting Author: Angelioudaki I

Authors: Angelioudaki I, Pantazatou V, Tzingounis A, Kataki A, Memos N,

Keywords: Extracellular vesicles, plasma, Gastroenteropancreatic NEN,

#4012 14 years of the Czech Neuroendocrine Tumors Registry

Introduction: Czech Cooperative Group for NETs was established on 22 April 2008. It continues with the practices of the Czech Carcinoid Group founded 1998. The Czech Neuroendocrine Registry was started in 2009 as a platform that should facilitate the data based on communication among various specialists treating NETs.

Conference:

Presenting Author:

Authors: Barkmanova J, Sedlackova E,

Keywords: neuroendocrine registry, population-based system, neuroendocrine tumor (NET),

#3974 Small extracellular vesicles miR-183-5p derived from highly invasive pancreatic neuroendocrine tumors reprogram macrophages towards SPP1+ macrophages

Introduction: Highly-metastatic (HM) pancreatic neuroendocrine tumors (pNETs) are characterized by an early occurrence of lymph node and liver metastases and a poor prognosis. Single-cell sequencing analysis showed that HM pNETs had remarkable infiltration of SPP1+ macrophages, which were involved in cell migration, angiogenesis and small extracellular vesicles (sEVs).

Conference:

Presenting Author:

Authors: Zhang W, Xu J, Lou X, Qin Y, Chen J,

Keywords: pancreatic neuroendocrine tumor, p53, small extracellular vesicles, macrophages, SPP1, biomarker,

#3622 Hypoxia down-regulates m6A methyltransferase METTL3 and WTAP promotes pancreatic neuroendocrine tumor metastasis via regulating TGFBI

Introduction: Hypoxia is a marker of cancer progression. When faced with hypoxia, tumor cells exhibit the dynamic change of N6-methyladenine (m6A). m6A is a reversible RNA modification that plays an important role in gene expression regulation and is closely related to the occurrence and development of various tumors.

Conference:

Presenting Author: Ye M

Authors: Ye M, Bai J, Tian Y, Chen J, Lu F,

Keywords: Pancreatic neuroendocrine tumor, RNA methyltransferase, exosomes, tumor-associated macrophages, tumor metastasis,

#3578 Optimal PLAnning of treatment and research of Neuroendocrine Tumors (NETs) in Australia: The PLANET registry and patient reported outcomes via PLANET App

Introduction: Neuroendocrine Neoplasms (NENs) are challenging to diagnose and manage due to their varied behaviour. Despite usually having an indolent course, they are often metastatic at diagnosis and can be associated with significant long-term morbidity and impaired quality-of-life (QOL). The PLANET registry was established to collate clinical data from tertiary NET centres and integrate these with real-time patient reported outcomes (PROs) enabled by the smartphone-based PLANET App.

Conference:

Presenting Author: Leyden S

Authors: Leyden S, Cummins M, Pavlakis N, Ransom D, Price T,

Keywords: data, PROMS, PROs, QOLs, real-world data,