Plasma extracellular vesicles number and size distinguish patients with neuroendocrine neoplasms

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Introduction: Neuroendocrine Neoplasms (NENs) are heterogeneous neoplasms, whose metastatic potential is challenging to predict. Extracellular vesicles (EVs) have been described as mediators of communication between the tumor cells and their microenvironment, driving the formation of metastatic niches.

Aim(s): Detection and characterization of EVs in gastroenteropancreatic NENs.

Materials and methods: Study cohort consisted of 23 patients with Intraductal Papillary Mucinous Neoplasm (IPMN, N=4, age:69±6.9), Neuroendocrine Tumors (NETs, N=14, age:66±2.8), Neuroendocrine Carcinomas (NECs, N=5, age:69±3.7), located in pancreas (19 pNEN), small intestine (2 siNEN), Vater ampulla (2 vaNEN). Plasma was serially centrifuged and monitored with Nanoparticle tracking analysis (NTA). Average concentration was calculated, and statistical tests were performed in IBM SPSS (v28).

Conference:

Presenting Author: Angelioudaki I

Authors: Angelioudaki I, Pantazatou V, Tzingounis A, Kataki A, Memos N,

Keywords: Extracellular vesicles, plasma, Gastroenteropancreatic NEN,