Abstract Library

#3405 A phase 2 open-label study of belzutifan (a HIF-2α inhibitor) monotherapy in patients with advanced/metastatic pheochromocytoma/paraganglioma or pancreatic neuroendocrine tumors

Introduction: Patients with advanced pheochromocytoma/paraganglioma (PPGL) or pancreatic neuroendocrine tumor (panNET) are in need of novel targeted therapies. Hypoxia-inducible factor 2α (HIF-2α) is one of the key oncogenic drivers in neuroendocrine tumors like PPGL and somatostatinomas. Hypoxia signaling pathway alterations or other mechanisms that stabilize HIFs are common in some PPGLs and panNETs. Belzutifan (MK-6482), a HIF-2α inhibitor, has shown antitumor activity in advanced renal cell carcinoma and von Hippel-Lindau (VHL) disease–associated tumors, including panNET.

Conference:

Presenting Author:

Authors: Jimenez C, Hadoux J, Del Rivero J, Das S, Iliopoulos O,

Keywords: pheochromocytoma, paraganglioma, pancreatic neuroendocrine tumor, belzutifan, MK-6482, metastatic,

#2138 Eterogeneity of Duodenal Neuroendocrine Tumors: A Multi-Centre Experience In Italy

Introduction: The optimal management of duodenal neuroendocrine neoplasms (dNENs) is unclear and endoscopic resection is increasingly performed instead of surgery.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Rossi R

Authors: Massironi S, Campana D, Partelli S, Panzuto F, Rossi R,

Keywords: duodenal neuroendocrine neoplasm, duodenum, gastrinoma, somatostatinoma, diagnosis, therap, guidelines,

#1785 Eterogeneity of Duodenal Neuroendocrine Tumors: A Multi-Centre Experience in Italy

Introduction: Duodenal neuroendocrine neoplasms (dNENs) are heterogeneous tumors, which could have a highly variable prognosis.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Rossi, Roberta Elisa r

Authors: Massironi S, Panzuto F, Rinzivillo M, Rossi R, Delle Fave G,

Keywords: duodenal neuroendocrine neoplasm, duodenum, gastrinoma, somatostatinoma, diagnosis, therapy guidelines,

#340 Aggressive Somatostatinoma, with Associated Pheocromocytoma in a Neurofibromatosis Patient

Introduction: Neurofibromatosis is associated with a neuroendocrine phenotype as pheocromocytoma, primary hyperparathyroidism and gastropancreatic neuroendocrine tumors.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Poiana C, Carsote M, Radoi V, Ene C, Gruia A,

Keywords: somatostatinoma, neurofibromatosis, pheocromocitoma, octreotidum,

#279 Coexistence of a Somatostatin-Producing Carcinoma of Duodenum and a Jejuna Gastrointestinal Stromal Tumor (GIST) in a Patient with Von Recklinghausen’s Disease

Introduction: Duodenal neuroendocrine tumors comprise 2-3% of all neuroendocrine tumors of the gastrointestinal tract. Coexistence of NF-1, NET and GIST is rare and only five cases have been described in the literature.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Daraki V, Stamou K, ?amalaki E, Spyrou F, Kalikakis G,

Keywords: somatostatinoma, Neurofibromatosis Type 1 , GIST, ,