Abstract Library

#3748 Association of MINEN with GIST on neurofibromatosis – A case report

Introduction: Although most digestive neuroendocrine tumors (NETs) are sporadic, around 5% of NETs occur in a context of hereditary predisposition, mainly type 1 multiple endocrine neoplasia (NEM1) and Von Hippel-Lindau disease (VHL).

Conference:

Presenting Author:

Authors: Samia K, Fatima H, Nabil B, Benali T, Aisha B,

Keywords: NEN, GIST, MINEN, DOG1,

#3526 Neurofibromatosis type 1 in combination with Pheochromocytoma (clinical case)

Introduction: Neurofibromatosis type 1 (NF-1) is a rare disease with characteristic pathological changes of the skin and nervous system, often in combination with abnormalities of other organs and systems. Endocrine neoplasms such as pheochromocytoma/paraganglioma, gastroenteropancreatic neuroendocrine tumors, thyroid tumors, and adrenal tumors, can also be rarely associated with NF-1.

Conference:

Presenting Author: Motrenko A

Authors: Motrenko A, Britvin T, Ilovayskaya I, Gurevich L,

Keywords: Neurofibromatos, pheochromocytoma, metanerins,

#985 Periampulary and Pancreatic Neuroendocrine Neoplasms with Duodenal Stromal Gastrointestinal Tumors in Patients with Type 1 Neurofibromatosis: Two Case Reports

Introduction: We describe two cases of neuroendocrine tumors (NETs) in patients with neurofibromatosis type 1 (NF1) associated with gastrointestinal stromal tumors (GISTs).

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Zerbi A

Authors: Ridolfi C, Gavazzi F, Spaggiari P, Carnaghi C, Lania A,

Keywords: pancreatic and ampullary neuroendocrine tumor, neurofibromatosis-1, GIST,

#701 High Expression of Mammalian Target of Rapamycin (mTOR) in NF1-Related Periampullary Neuroendocrine Tumors

Introduction: Neurofibromatosis type 1 (NF1) is a rare inherited disorder associated with cutaneous lesions and neoplasms in the nervous and gastroenteropancreatic systems, including periampullary NETs. NF1-coded protein, neurofibromin, is a tumor suppressor that negatively regulates the mammalian target of rapamycin (mTOR). Preclinical in vitro and in vivo studies demonstrated a constitutive activation of mTOR pathway associated with significant antineoplastic effects of mTOR inhibitors in NF1-related glial tumor models.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Razzore P

Authors: Razzore P, Volante M, Russolillo N, Motta M, Lacidogna G,

Keywords: NF1, periampullar NETs, mTOR ,

#615 Gastrinoma and Neurofibromatosis Type 2: Is There an Association?

Introduction: Gastroenteropancreatic neuroendocrine tumors have been seldom described in association with neurofibromatosis type-1, whereas an association with neurofibromatosis type-2 (NF2) has never been reported.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Rossi R

Authors: Massironi S, Zilli A, Cavalcoli F, Rossi R, Conte D,

Keywords: Gastrinoma, neurofibromatosis type-2, MEN-1,