Abstract Library

#985 Periampulary and Pancreatic Neuroendocrine Neoplasms with Duodenal Stromal Gastrointestinal Tumors in Patients with Type 1 Neurofibromatosis: Two Case Reports

Introduction: We describe two cases of neuroendocrine tumors (NETs) in patients with neurofibromatosis type 1 (NF1) associated with gastrointestinal stromal tumors (GISTs).

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Zerbi A

Authors: Ridolfi C, Gavazzi F, Spaggiari P, Carnaghi C, Lania A,

Keywords: pancreatic and ampullary neuroendocrine tumor, neurofibromatosis-1, GIST,

#701 High Expression of Mammalian Target of Rapamycin (mTOR) in NF1-Related Periampullary Neuroendocrine Tumors

Introduction: Neurofibromatosis type 1 (NF1) is a rare inherited disorder associated with cutaneous lesions and neoplasms in the nervous and gastroenteropancreatic systems, including periampullary NETs. NF1-coded protein, neurofibromin, is a tumor suppressor that negatively regulates the mammalian target of rapamycin (mTOR). Preclinical in vitro and in vivo studies demonstrated a constitutive activation of mTOR pathway associated with significant antineoplastic effects of mTOR inhibitors in NF1-related glial tumor models.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Razzore P

Authors: Razzore P, Volante M, Russolillo N, Motta M, Lacidogna G,

Keywords: NF1, periampullar NETs, mTOR ,

#615 Gastrinoma and Neurofibromatosis Type 2: Is There an Association?

Introduction: Gastroenteropancreatic neuroendocrine tumors have been seldom described in association with neurofibromatosis type-1, whereas an association with neurofibromatosis type-2 (NF2) has never been reported.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Rossi R

Authors: Massironi S, Zilli A, Cavalcoli F, Rossi R, Conte D,

Keywords: Gastrinoma, neurofibromatosis type-2, MEN-1,

#525 Pancreatic Neuroendocrine Tumors Associated with Mesenchimal Neoplasms of the GI Tract

Introduction: Neuroendocrine pancreatic tumors (NPT) are occasionally associated with mesenchimal tumors in neurofibromatosis type 1 but rarely in sporadic cases. We report five cases of NPT associated with other rare mesenchimal neoplasms of the GI tract, observed in our Department from 2003 to 2011.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Moletta L, Milanetto A, Alaggio R, Sperti C, Pedrazzoli S,

Keywords: pancreatic neuroendocrine tumors, GIST, pancreatic resection,

#340 Aggressive Somatostatinoma, with Associated Pheocromocytoma in a Neurofibromatosis Patient

Introduction: Neurofibromatosis is associated with a neuroendocrine phenotype as pheocromocytoma, primary hyperparathyroidism and gastropancreatic neuroendocrine tumors.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Poiana C, Carsote M, Radoi V, Ene C, Gruia A,

Keywords: somatostatinoma, neurofibromatosis, pheocromocitoma, octreotidum,