Abstract Library

#2037 Stromal Immune Contexture Predicts Disease-Free Survival in Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NENs)

Introduction: Stromal Immune Contexture (SIC) helps predict prognosis in solid Tumors (T) but has been poorly investigated in gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs). We tested whether GEP-NENs profiling for adaptive immunity-related SIC markers, as well as inflammatory (COX2),EMT [Beta-catenin (B-cat)] and oncogenic pathway signaling (pS6) markers,could improve Ki67 and/or MO-based prediction of OS and DFS.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Milione M

Authors: Milione M, Miceli R, Pellegrinelli A, Spaggiari P, Tagliabue G,

Keywords: Neuroendocrine, Ki-67, Morphology, Immune contexture, PDL1, Beta-Catenin,

#2033 Ki-67 and Presence of Liver Metastases Predicts Progression in Pancreatic Neuroendocrine Neoplasms (pNENs)

Introduction: In pancreatic neuroendocrine neoplasms (pNENs), size ≤20 mm and Ki-67 ≤2% suggest indolent behavior, but no factor alone can predict prognosis.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Milione M

Authors: Milione M, Maisonneuv P, Pellegrinelli A, Spaggiari P, Centonze G,

Keywords: Ki-67, Prognosis, Pancreas, Neuroendocrine, size, liver metastases, Biopsy, Surgical,

#1446 Morphological Differentiation and Ki67-Index Are Predictive of Prognosis Independently of the Type of Therapy in Gastroenteropancreatic Neuroendocrine Carcinomas (NECs)

Introduction: Gastroenteropancreatic (GEP) neuroendocrine carcinomas (NECs) are considered an heterogeneous category.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Milione M

Authors: Milione M, Maisonneuve P, Spada F, Pellegrinelli A, Spaggiari P,

Keywords: Ki-67, OS, PFS, NEC,

#1204 Clinico-Pathologic and Survival Analysis of 211 GastroEnteroPancreatic G3 Neuroendocrine Carcinomas (GEP-NECs)

Introduction: GEP-NECs show Ki67>20% and/or >20 mitoses x10 HPF. Mixed AdenoNeuroendocrine Carcinomas (MANECs) are mixed exocrine-neuroendocrine neoplasms. NECs are associated with poor prognosis but recent findings have suggested that there is a fraction of patients showing a better than expected survival rate.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Milione M

Authors: Milione M, Spada F, Maisonneuve P, Pusceddu S, Spaggiari P,

Keywords: NEC, Ki67, MANEC, PROGNOSIS,

#985 Periampulary and Pancreatic Neuroendocrine Neoplasms with Duodenal Stromal Gastrointestinal Tumors in Patients with Type 1 Neurofibromatosis: Two Case Reports

Introduction: We describe two cases of neuroendocrine tumors (NETs) in patients with neurofibromatosis type 1 (NF1) associated with gastrointestinal stromal tumors (GISTs).

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Zerbi A

Authors: Ridolfi C, Gavazzi F, Spaggiari P, Carnaghi C, Lania A,

Keywords: pancreatic and ampullary neuroendocrine tumor, neurofibromatosis-1, GIST,