Abstract Library

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#2037 Stromal Immune Contexture Predicts Disease-Free Survival in Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NENs)

Introduction: Stromal Immune Contexture (SIC) helps predict prognosis in solid Tumors (T) but has been poorly investigated in gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs). We tested whether GEP-NENs profiling for adaptive immunity-related SIC markers, as well as inflammatory (COX2),EMT [Beta-catenin (B-cat)] and oncogenic pathway signaling (pS6) markers,could improve Ki67 and/or MO-based prediction of OS and DFS.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Milione M

Authors: Milione M, Miceli R, Pellegrinelli A, Spaggiari P, Tagliabue G,

Keywords: Neuroendocrine, Ki-67, Morphology, Immune contexture, PDL1, Beta-Catenin,

#2033 Ki-67 and Presence of Liver Metastases Predicts Progression in Pancreatic Neuroendocrine Neoplasms (pNENs)

Introduction: In pancreatic neuroendocrine neoplasms (pNENs), size ≤20 mm and Ki-67 ≤2% suggest indolent behavior, but no factor alone can predict prognosis.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Milione M

Authors: Milione M, Maisonneuv P, Pellegrinelli A, Spaggiari P, Centonze G,

Keywords: Ki-67, Prognosis, Pancreas, Neuroendocrine, size, liver metastases, Biopsy, Surgical,

#1755 Immune-Related Factors Analysis Enhances the Stratification of GEP-NENs Patients Into Distinct Prognostic Subsets

Introduction: Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are divided into different prognostic categories according to Ki67 class (≤2%: 2%-20%; 20%-55%; >55%); treatment strategies based on this classification are not fully effective.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Milione M

Authors: Milione M, Miceli R, Pellegrinelli A, Centonze G, Barretta F,

Keywords: Ki67, immune-related markers, disease-free survival, PD-L1,

#1753 Ki67 Is Able to Predict Pancreatic NENs Prognosis Irrespective of Their Size

Introduction: In pancreatic neuroendocrine neoplasms (pNENs), size <20mm and Ki67≤2% suggest indolent behavior. None of these factors alone predicts prognosis. No other predictive factors have been suggested.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Milione M

Authors: Milione M, Maisonneuve P, Pellegrinelli A, Centonze G, Coppa J,

Keywords: Ki67, PFS, pancreatic, NEN,

#1451 Pancreatic NENs <2 cm Could Represent a New Entity Worth of Further Investigation

Introduction: Surgical approach to the treatment of well-differentiated pancreatic neuroendocrine neoplasms (pNENs) is based on tumor size and Ki67. Surgical removal is not recommended for tumors <2cm, due to their indolent nature. Ki67≤2% and size <2cm are considered indicative of benign tumors. However, size and Ki67 may not correctly predict the prognosis of patients with pNENs <2cm.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Milione M

Authors: Milione M, Maisonneuve P, Alessio P, Centonze G, Coppa J,

Keywords: NEN, <2cm, prognosis,