Abstract Library

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#3639 Tumor uptake on 18FDOPA PET/CT is a strong prognostic factor in patients with metastatic small intestine neuroendocrine tumors (siNETs) – A GTE study

Introduction: 18FDOPA PET/CT has high diagnostic performances for siNETs. Its prognostic role is unknown.

Conference:

Presenting Author: de Mestier L

Authors: de Rycke O, Imperiale A, Perrier M, Bando-Delaunay A, Mennetrey C,

Keywords: FDOPA PET/CT, prognosis, small intestine NETs,

#2037 Stromal Immune Contexture Predicts Disease-Free Survival in Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NENs)

Introduction: Stromal Immune Contexture (SIC) helps predict prognosis in solid Tumors (T) but has been poorly investigated in gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs). We tested whether GEP-NENs profiling for adaptive immunity-related SIC markers, as well as inflammatory (COX2),EMT [Beta-catenin (B-cat)] and oncogenic pathway signaling (pS6) markers,could improve Ki67 and/or MO-based prediction of OS and DFS.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Milione M

Authors: Milione M, Miceli R, Pellegrinelli A, Spaggiari P, Tagliabue G,

Keywords: Neuroendocrine, Ki-67, Morphology, Immune contexture, PDL1, Beta-Catenin,

#2033 Ki-67 and Presence of Liver Metastases Predicts Progression in Pancreatic Neuroendocrine Neoplasms (pNENs)

Introduction: In pancreatic neuroendocrine neoplasms (pNENs), size ≤20 mm and Ki-67 ≤2% suggest indolent behavior, but no factor alone can predict prognosis.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Milione M

Authors: Milione M, Maisonneuv P, Pellegrinelli A, Spaggiari P, Centonze G,

Keywords: Ki-67, Prognosis, Pancreas, Neuroendocrine, size, liver metastases, Biopsy, Surgical,

#1755 Immune-Related Factors Analysis Enhances the Stratification of GEP-NENs Patients Into Distinct Prognostic Subsets

Introduction: Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are divided into different prognostic categories according to Ki67 class (≤2%: 2%-20%; 20%-55%; >55%); treatment strategies based on this classification are not fully effective.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Milione M

Authors: Milione M, Miceli R, Pellegrinelli A, Centonze G, Barretta F,

Keywords: Ki67, immune-related markers, disease-free survival, PD-L1,

#1753 Ki67 Is Able to Predict Pancreatic NENs Prognosis Irrespective of Their Size

Introduction: In pancreatic neuroendocrine neoplasms (pNENs), size

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Milione M

Authors: Milione M, Maisonneuve P, Pellegrinelli A, Centonze G, Coppa J,

Keywords: Ki67, PFS, pancreatic, NEN,