Abstract Library

#3323 Anti-immune defences involving down-regulation of MHC-I or beta-catenin activation do not explain immune coldness of pancreatic or ileal neuroendocrine tumors

Introduction: Our previous study demonstrated pancreatic (PNET) and ileal neuroendocrine tumors (INETs) are immunologically cold, containing very few tumor infiltrating lymphocytes (TILs) compared to non-small cell lung cancers. This raises the questions of whether there is in fact, a weak anti-tumor immune response taking place or whether the tumors are deploying effective anti-immune defences such as down-regulation of MHC class I or activation of β-catenin signalling.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Tanno L

Authors: Tanno L, Naheed S, Lopez M, Taylor J, Machado M,

Keywords: pancreatic neuroendocrine tumor, ileal neuroendocrine tumor, beta-catenin pathway, tumor immune microenvironment, major histocompatibility complex 1,

#3251 Impact of Wnt signalling on CXCR4 expression and function

Introduction: Loss of Somatostatin Receptor 2 (SSTR2) expression and rising Chemokine Receptor Type 4 (CXCR4) expression are associated with increasing dedifferentiation in Neuroendocrine Tumors (NET). CXCR4 expression is associated with enhanced metastatic and invasive potential and worse prognosis in NET, but might be a theranostic target in NET not sufficiently expressing SSTR2. Likewise, aberrant activation of Wnt/β-catenin signalling may promote a more aggressive phenotype in NET.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Weich A

Authors: Weich A, Rogoll D, Mayer L, Meining A, Kudlich T,

Keywords: neuroendocrine, NET, CXCR4, Wnt, Wnt Signalling, beta-catenin, BON-1, QGP-1,

#3242 Establishment and characterization of a new neuroendocrine carcinoma cell model

Introduction: The development of treatment strategies for neuroendocrine carcinomas (NEC) requires in vitro models expressing NEC–specific targets. The CXC Chemokine Receptor Type 4 (CXCR4), that is expressed in NEC with decreasing differentiation, as well as factors involved in chemotherapy resistance may represent such targets.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Weich A

Authors: Weich A, Schreiner J, Rogoll D, Werner R, Meining A,

Keywords: neuroendocrine, net, CXCR4, Wnt signalling, beta-catenin, BON-1, QGP-1,

#2037 Stromal Immune Contexture Predicts Disease-Free Survival in Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NENs)

Introduction: Stromal Immune Contexture (SIC) helps predict prognosis in solid Tumors (T) but has been poorly investigated in gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs). We tested whether GEP-NENs profiling for adaptive immunity-related SIC markers, as well as inflammatory (COX2),EMT [Beta-catenin (B-cat)] and oncogenic pathway signaling (pS6) markers,could improve Ki67 and/or MO-based prediction of OS and DFS.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Milione M

Authors: Milione M, Miceli R, Pellegrinelli A, Spaggiari P, Tagliabue G,

Keywords: Neuroendocrine, Ki-67, Morphology, Immune contexture, PDL1, Beta-Catenin,

#182 Ki-67 (MIB-1) Proliferative Activity and Beta-Catenin Immunoexpression in Liver Metastases of Gastroenteropancreatic Neuroendocrine Tumors

Introduction: Assessment of liver metastases biology features associated with cell proliferation and adhesion has a strong prognostic impact in patients with gastroenteropancreatic (GEP) neuroendocrine carcinomas.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Delektorskaya V, Chemeris G, Pavlovskaya A,

Keywords: Ki-67 labeling index, beta-catenin, neuroendocrine carcinomas, liver metastases, immunohistochemistry,