Abstract Library

#3444 Earlier diagnosis of Neuroendocrine Tumors (NETs) through transformation of the South Wales NET Service

Introduction: Neuroendocrine tumors (NETs) are heterogeneous cancers, arising mainly from the gastroenteropancreatic tract. Delayed diagnosis and mislabelling are widely recognised internationally in midgut NETs with little data describing how to improve diagnosis times. In 2017, transformation of the South Wales NET Service included a change to a gastroenterology-led service model, alongside education and forming working relationships with gastroenterologists and surgeons.

Conference:

Presenting Author:

Authors: Gould H, Kapish A, Karategos T, Abbas S, Taylor R,

Keywords: midgut NET, midgut neuroendocrine tumor, diagnosis, diagnostic delay, investigation, mislabel, imaging,

#3341 A rare case of oligometastatic thymic carcinoid

Introduction: Primary thymic neuroendocrine tumors (NETs) are a rare type of cancer which have a propensity to local or distant spread to nodes, lung, and bone. Treatment consists of a combination of surgery, SACT and radiotherapy, depending on the stage.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Cooper J

Authors: Cooper J, Jethwa D, Zen Y, Prachalis A, Taylor B,

Keywords: thymic carcinoid, oligometastatic disease,

#3323 Anti-immune defences involving down-regulation of MHC-I or beta-catenin activation do not explain immune coldness of pancreatic or ileal neuroendocrine tumors

Introduction: Our previous study demonstrated pancreatic (PNET) and ileal neuroendocrine tumors (INETs) are immunologically cold, containing very few tumor infiltrating lymphocytes (TILs) compared to non-small cell lung cancers. This raises the questions of whether there is in fact, a weak anti-tumor immune response taking place or whether the tumors are deploying effective anti-immune defences such as down-regulation of MHC class I or activation of β-catenin signalling.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Tanno L

Authors: Tanno L, Naheed S, Lopez M, Taylor J, Machado M,

Keywords: pancreatic neuroendocrine tumor, ileal neuroendocrine tumor, beta-catenin pathway, tumor immune microenvironment, major histocompatibility complex 1,

#2811 Improving Diagnosis Times as Part of the Transformation of the South Wales NET Service

Introduction: Transformation of the South Wales NET service in late 2017 introduced new specialised staff, gastroenterology-led clinics and improved MDTs with a particular emphasis on educating referring specialties. This has led to improved overall patient experience, satisfaction and quality of life. NETs are recognised world-wide for their lengthy diagnosis times.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Amin K

Authors: Amin K, Gruber M, Shayan-Arani H, Taylor R, Powell C,

Keywords: neuroendocrine, tumours, diagnosis, survival, gastroenterology, surgery, new service, nets, south wales, midgut, pancreatic, paraganglioma, incidental,

#1148 Ki67 as a Prognostic Marker in Neuroendocrine Tumours: A Systematic Review of the Literature and Quantitative Synthesis of 5 year Survival Data

Introduction: The ENETS guidelines classify Gastroenteropancreatic Neuroendocrine Tumours (GEP NETs) according to the histological assessment of tumour mitotic count or Ki67 labelling index (LI) on paraffin-embedded tissue, because proliferation rate has been shown to strongly correlate with prognosis. Since the guidelines were published, Ki67 has been established as the more reproducible measure, and further large case series have been reported.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Cave J

Authors: Richards-Taylor S, Tilley C, Hu J, Pearce N, Armstrong T,

Keywords: GEP-NET, prognosis, Ki67,