Abstract Library
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ENETS Abstract Search
Introduction: Rb and p53 status may help distinguishing well from poorly differentiated neuroendocrine neoplasms (NEN) and may predict response to chemotherapy. Studies correlating Rb/p53 genetic and immunohistochemistry were performed on high-quality frozen samples with high throughput techniques efficient for copy number determination. This situation differs from routine practice in which small deletions may be hard to detect on formalin-fixed paraffin-embedded (FFPE) samples with a gene panel approach.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Cros J
Authors: Chen R, Lacroix L, De Rycke O, Lacombe C, Cazes A,
Keywords: rb, p53, aggressive neuroendocrine tumors, biomarker,
Introduction: Liver metastasis (LM) are very frequent (65-95%) and represent a crucial prognostic factor in patients with gastroenteropancreatic neuroendocrine neoplasms (GEP NENs). The paucity of relevant experimental models has limited the understanding of the pathophysiology of NENs and the development of efficient therapeutic strategies
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Doornebal E
Authors: Doornebal E, Harris N, Miquel R, Zen Y, Pizanias M,
Keywords: Liver, neuroendocrine liver metastasis, ex-vivo model, personalized medicine, immunocompetent, organotypic tissue slices,
#2692 Development of Ex-Vivo Models of Metastatic Neuroendocrine Neoplasms
Introduction: The lack of relevant in-vivo and in-vitro models has precluded investigations of the pathophysiology of metastatic NENs. Organotypic tumour slices retain the complexity of tumours in-vivo without extensive manipulation of the tissue.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Srirajaskanthan R
Authors: Srirajaskanthan R, Doornebal E, Harris N, Zen Y, Pizanias M,
Keywords: ex-vivo, organotypic tumour slices, immune environment, models,
Introduction: The mTOR inhibitor Everolimus is approved for the treatment of PanNET and no predictive biomarker is available. mTOR is a central node controlling mitochondrial and aerobic glycolytic metabolisms.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author:
Authors: Cros J, Bucau M, Raffenne J, Soukeur M, Dumont F,
Keywords: mTOR, everolimus, pancreatic NET, metabolism,
Introduction: Liver transplantation (LT) has been prosed as a curative treatment for metastatic gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) but there is a lack of consensus on its real benefit when compared with hepatectomy.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Ruzzenente A
Authors: Ruzzenente A, Bagante F, Aldrighetti L, Ercolani G, Giuliante F,
Keywords: Surgery, Liver Metastases, Hepatectomy,