Abstract Library

Welcome to the open-access search for all ENETS abstracts presented at the Annual ENETS Conferences.

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ENETS Abstract Search

#3323 Anti-immune defences involving down-regulation of MHC-I or beta-catenin activation do not explain immune coldness of pancreatic or ileal neuroendocrine tumors

Introduction: Our previous study demonstrated pancreatic (PNET) and ileal neuroendocrine tumors (INETs) are immunologically cold, containing very few tumor infiltrating lymphocytes (TILs) compared to non-small cell lung cancers. This raises the questions of whether there is in fact, a weak anti-tumor immune response taking place or whether the tumors are deploying effective anti-immune defences such as down-regulation of MHC class I or activation of β-catenin signalling.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Tanno L

Authors: Tanno L, Naheed S, Lopez M, Taylor J, Machado M,

Keywords: pancreatic neuroendocrine tumor, ileal neuroendocrine tumor, beta-catenin pathway, tumor immune microenvironment, major histocompatibility complex 1,

#3322 Analysis of immune landscape in pancreatic and ileal neuroendocrine tumors demonstrates an immune cold tumor microenvironment

Introduction: Neuroendocrine tumors (NETs) are rare tumors with an increasing incidence. While low and intermediate-grade pancreatic (PNET) and ileal (INET) tumors are slow-growing, they have a relatively high rate of metastasis to the liver where the outcome is much worse. For most cancers, the outcome is determined by the quality of the anti-tumor immune response. However, the quality and significance of anti-tumor responses in NETs are incompletely understood.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Tanno L, Naheed S, Dunbar J, Tod J, Lopez M,

Keywords: pancreatic neuroendocrine tumor, ileal neuroendocrine tumor, tumor immune microenvironment, tumor infiltrating lymphocytes,

#3037 Effects of Debulking Surgery, Transarterial Embolisation (TAE) and Transarterial Chemoembolisation (TACE) on Quality of Life in Patients with Metastatic Ileal and Pancreatic Neuroendocrine Tumours (NETs)

Introduction: Debulking surgery, TAE and TACE procedures are undertaken in patients with metastatic NETs. Reducing the physical burden of disease may prolong survival and can improve the quality of life of patients. However, there is only limited quality of life data available after surgery despite the fact that is has been used routinely for many years.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Sinclair A, Tanno L, Jarvis E, Ramsey E, Naheed S,

Keywords: Quality of Life, Debulking Surgery, TAE, TACE, Metastatic, NETs,