Abstract Library

#3456 Clinicopathological characteristics and treatment options of the new grade 3 neuroendocrine tumor subgroup (NETs G3)

Introduction: NET G3 is a new subgroup of well-differentiated NENs. The impact of morphological characteristics on clinical course and treatment tactics is still questionable.

Conference:

Presenting Author: Evdokimova E

Authors: Evdokimova E, Artamonova E, Chemeris G, Yemelyanova G, Markovich A,

Keywords: NET G3, SSTR, ki67, somatostatin analogues,

#3151 Immunohistochemical evaluation of vimentin aberrant expression in lung carcinoid tumors

Introduction: The carcinoid tumors of lung represent a rare group of epithelial well-differentiated neuroendocrine neoplasms with common morphological characteristics and highly variable clinical course. Vimentin is a type III intermediate filament that is involved in cell migration and adhesion. Vimentin also drives epithelial to mesenchymal transition (EMT) and metastasis in solid tumors. However, no information exists for vimentin expression levels and the characterization of EMT phenotypes of lung carcinoid tumors.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Delektorskaya V, Chemeris G, Smirnova E,

Keywords: lung carcinoid tumor, vimentin, immunohistochemistry, diagnosis,

#886 Expression Patterns of Cellular Retinoic Acid Binding Protein-I in Neuroendocrine Tumors of the Lung: A Pilot Immunohistochemical Study

Introduction: Cellular retinoic acid binding protein-I (CRABP-I), a member of the lipid-binding proteins family, plays an important role in retinoic acid-mediated cell proliferation and is essential for the development of various malignant neoplasms. The actual role of CRABP-I in tumor progression remains unknown.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Delektorskaya V, Chemeris G, Zborovskaya I,

Keywords: neuroendocrine tumor, lung, immunohistochemistry,

#182 Ki-67 (MIB-1) Proliferative Activity and Beta-Catenin Immunoexpression in Liver Metastases of Gastroenteropancreatic Neuroendocrine Tumors

Introduction: Assessment of liver metastases biology features associated with cell proliferation and adhesion has a strong prognostic impact in patients with gastroenteropancreatic (GEP) neuroendocrine carcinomas.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Delektorskaya V, Chemeris G, Pavlovskaya A,

Keywords: Ki-67 labeling index, beta-catenin, neuroendocrine carcinomas, liver metastases, immunohistochemistry,

#87 Alterations of E-cadherin, beta-catenin and caveolin-1 expression in gastroenteropancreatic neuroendocrine tumors

Introduction: Gastroenteropancreatic neuroendocrine tumors (GEP NETs) comprise a heterogeneous group of neoplasm with different histological patterns and biological behavior. Only limited information is available on immunohistochemical prognostic factors of disease. Alterations in the cell-cell adhesion system are closely associated with cell invasion and metastasis in many malignancies, including those of endocrine origin. Abnormal expression of E-cadherin and beta-catenin has been reported to play an important role in these processes. Caveolin-1 has recently been identified as a tumor metastasis modifier factor, which might increase the cell metastasis potential through the interaction with E-cadherin. However, the role of caveolin-1 in GEP NETs cell invasion remains unknown.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Delektorskaya V, Chemeris G,

Keywords: immunohistochemistry, E-cadherin, beta-catenin, caveolin-1, cyclin D1, Ki67, gastroenteropancreatic neuroendocrine tumors, metastasis,