Expression Patterns of Cellular Retinoic Acid Binding Protein-I in Neuroendocrine Tumors of the Lung: A Pilot Immunohistochemical Study

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Introduction: Cellular retinoic acid binding protein-I (CRABP-I), a member of the lipid-binding proteins family, plays an important role in retinoic acid-mediated cell proliferation and is essential for the development of various malignant neoplasms. The actual role of CRABP-I in tumor progression remains unknown.

Aim(s): To investigate the expression patterns of CRABP-I in the different subtypes of the lung neuroendocrine tumors (NETs).

Materials and methods: CRABP-I expression was evaluated by immunohistochemistry in 57 histopathologically confirmed lung NETs, including 25 typical carcinoids, nine atypical carcinoids, 18 small cell lung carcinomas (SCLCs), five large cell neuroendocrine carcinomas (LCNECs).

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Delektorskaya V, Chemeris G, Zborovskaya I,

Keywords: neuroendocrine tumor, lung, immunohistochemistry,