Immunohistochemical evaluation of vimentin aberrant expression in lung carcinoid tumors

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Introduction: The carcinoid tumors of lung represent a rare group of epithelial well-differentiated neuroendocrine neoplasms with common morphological characteristics and highly variable clinical course. Vimentin is a type III intermediate filament that is involved in cell migration and adhesion. Vimentin also drives epithelial to mesenchymal transition (EMT) and metastasis in solid tumors. However, no information exists for vimentin expression levels and the characterization of EMT phenotypes of lung carcinoid tumors.

Aim(s): The aim of the study was to assess the vimentin aberrant expression in the carcinoid tumors of lung, and correlate the expression to clinicopathological features, Ki67 levels, and prognosis.

Materials and methods: Vimentin expression was studied using immunohistochemical analysis in tumors of 34 patients with lung carcinoid tumors, which included 17 cases in the categories of typical and atypical carcinoids.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Delektorskaya V, Chemeris G, Smirnova E,

Keywords: lung carcinoid tumor, vimentin, immunohistochemistry, diagnosis,