#3251
Impact of Wnt signalling on CXCR4 expression and function
Introduction:
Loss of Somatostatin Receptor 2 (SSTR2) expression and rising Chemokine Receptor Type 4 (CXCR4) expression are associated with increasing dedifferentiation in Neuroendocrine Tumors (NET). CXCR4 expression is associated with enhanced metastatic and invasive potential and worse prognosis in NET, but might be a theranostic target in NET not sufficiently expressing SSTR2. Likewise, aberrant activation of Wnt/β-catenin signalling may promote a more aggressive phenotype in NET.
Conference:
18th Annual ENETS Concerence (2021)
Presenting Author:
Weich A
Authors:
Weich A,
Rogoll D,
Mayer L,
Meining A,
Kudlich T,
Keywords:
neuroendocrine,
NET,
CXCR4,
Wnt,
Wnt Signalling,
beta-catenin,
BON-1,
QGP-1,
#3242
Establishment and characterization of a new neuroendocrine carcinoma cell model
Introduction:
The development of treatment strategies for neuroendocrine carcinomas (NEC) requires in vitro models expressing NEC–specific targets. The CXC Chemokine Receptor Type 4 (CXCR4), that is expressed in NEC with decreasing differentiation, as well as factors involved in chemotherapy resistance may represent such targets.
Conference:
18th Annual ENETS Concerence (2021)
Presenting Author:
Weich A
Authors:
Weich A,
Schreiner J,
Rogoll D,
Werner R,
Meining A,
Keywords:
neuroendocrine,
net,
CXCR4,
Wnt signalling,
beta-catenin,
BON-1,
QGP-1,
#3222
Impact of Wnt signalling on somatostatin receptor (SSTR) expression and function
Introduction:
Somatostatin receptors (SSTR) are expressed by most differentiated neuroendocrine tumors (NET) and are important treatment targets. Loss of SSTR expression is associated with a worse prognosis. Deregulation of Wnt/β-catenin signalling has been demonstrated in NET. Treatment with the Wnt inhibitor 5-aza-2'-deoxycytidine (5-aza-CdR) led to growth inhibition in a NET tumor cell line. Other data show an increase in SSTR2 mRNA expression and cellular uptake of radiolabelled octreotide in NET cell lines after incubation with 5-aza-CdR.
Conference:
18th Annual ENETS Concerence (2021)
Presenting Author:
Weich A
Authors:
Weich A,
Rogoll D,
Mayer L,
Peschka M,
Meining A,
Keywords:
NET,
Wnt Signalling,
somatostatin receptor,
BON-1,
QGP-1,
SSTR,
