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#3222 Impact of Wnt signalling on somatostatin receptor (SSTR) expression and function

Introduction: Somatostatin receptors (SSTR) are expressed by most differentiated neuroendocrine tumors (NET) and are important treatment targets. Loss of SSTR expression is associated with a worse prognosis. Deregulation of Wnt/β-catenin signalling has been demonstrated in NET. Treatment with the Wnt inhibitor 5-aza-2'-deoxycytidine (5-aza-CdR) led to growth inhibition in a NET tumor cell line. Other data show an increase in SSTR2 mRNA expression and cellular uptake of radiolabelled octreotide in NET cell lines after incubation with 5-aza-CdR.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Weich A

Authors: Weich A, Rogoll D, Mayer L, Peschka M, Meining A,

Keywords: NET, Wnt Signalling, somatostatin receptor, BON-1, QGP-1, SSTR,