Immune-Related Factors Analysis Enhances the Stratification of GEP-NENs Patients Into Distinct Prognostic Subsets

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Introduction: Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are divided into different prognostic categories according to Ki67 class (≤2%: 2%-20%; 20%-55%; >55%); treatment strategies based on this classification are not fully effective.

Aim(s): Prognostic role of immune-related markers has not been investigated.

Materials and methods: We characterized by IHC primitive tumors and surrounding stroma from 136 GEP-NENs patients (pts). A validated quantitative score combining expression and intensity was used. Prognosis was evaluated in terms of disease-free survival (DFS). Variables were selected according to their significance in a random forest (RF) model and further analyzed with multivariable Cox model to predict 5-year DFS.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Milione M

Authors: Milione M, Miceli R, Pellegrinelli A, Centonze G, Barretta F,

Keywords: Ki67, immune-related markers, disease-free survival, PD-L1,