Pancreatic NENs <2 cm Could Represent a New Entity Worth of Further Investigation

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Introduction: Surgical approach to the treatment of well-differentiated pancreatic neuroendocrine neoplasms (pNENs) is based on tumor size and Ki67. Surgical removal is not recommended for tumors <2cm, due to their indolent nature. Ki67≤2% and size <2cm are considered indicative of benign tumors. However, size and Ki67 may not correctly predict the prognosis of patients with pNENs <2cm.

Aim(s): The combined use of Ki67 and morphological parameters could allow different prognostic categories in pNENs <2 cm.

Materials and methods: 75 patients (33≤2 cm, 42>2cm; 35 G1, 36 G2, 4 G3) were evaluated. All patients with <2cm tumor had received surgical treatment.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Milione M

Authors: Milione M, Maisonneuve P, Alessio P, Centonze G, Coppa J,

Keywords: NEN, <2cm, prognosis,