Neuroendocrine Tumors, Searching for New Prognostic Biomarkers Abstract #682

Introduction: Neuroendocrine tumors (NET) of the digestive system were once considered relatively rare, however, the incidence is increasing. New prognostic biomarkers are needed for assessment of tumor behavior to inform patient treatment and improve outcome. The proliferation marker, Ki-67, is used for NET grading. Although classified as low grade, some tumors actually develop metastases.
Aim(s): To determine if other proliferation and/or apoptotic markers could distinguish between metastatic and non-metastatic low grade NET.
Materials and methods: Immunohistochemistry was done for proliferation marker, Mini Chromosome Maintenance 4 (MCM4) and pro-apoptosis marker, Apoptosis-stimulating of p53 protein 2 (ASPP2). Thirty-six low grade digestive NETs either with or without metastasis were studied.
Conference: 10th Annual ENETS Conference (2013)
Category: Biomarkers
Presenting Author: Helen Miller

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