Abstract Library

#309 The Utility of Alpha Internexin as a Predictive Tissue Biomarker for Proliferation in Gastrointestinal and Pancreatic Neuroendocrine Tumors

Introduction: GEP-NETs are increasing but Ki-67 and CgA provide limited information regarding malignancy. A key unmet need is alternative biomarkers to assess the likelihood of local invasion or metastasis.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Schimmack S, Lawrence B, Svejda B, Fischer L, Schmitz-Winnenthal H,

Keywords: alpha-internexin, biomarker, GEP-NET, INA, Ki-67, malignancy, metastasis, neuroendocrine tumor, PCR,

#126 Assessment of the proliferation marker Ki-67 by endoscopic ultrasound guided-Fine Needle Aspiration (EUS-FNA) in pancreatic endocrine tumors: A comparative analysis with histology of the surgical specimen

Introduction: Assessment of the proliferative index by Ki-67 immuno-labelling is an important prognostic parameter for the biologic behavior of digestive neuroendocrine tumors, usually established on the histological specimen obtained after surgery or macro-biopsy. However, small pancreatic endocrine tumors (PET) are more and more often recognized by CT/MRI and diagnosed by EUS. The value of Ki-67 labelling index (Ki-67-LI) on fine needle aspiration (FNA) is not well-established in this setting, although regularly assessed.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Borbath I

Authors: Bernard V, Weynand B, Jouret-Mourin A, Gigot J, Hubert C,

Keywords: pancreatic endocrine tumor, endoscopic ultrasound, Ki-67, prognosis,