Abstract Library

#1009 Streptozotocin-Based Chemotherapy is Still Alive in Patients with Neuroendocrine Neoplasms: Predictive and Prognostic Markers for Treatment und Survival

Introduction: Chemotherapy with Streptozotocin (STZ) and 5-FU or Doxorubicin (Doc) represents a standard of care for patients with well-differentiated metastatic neuroendocrine neoplasms, especially for the pancreas (PNENs). However, data to identify predictive and prognostic markers are limited.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Krug S, Boch M, Rinke A, Müller D, König A,

Keywords: streptozotocin, NEN, 5-fluorouracil, Doc,

#825 Brain Metastases in Neuroendocrine Tumor Patients: Frequency and Outcome

Introduction: Brain metastases are rarely reported in patients with neuroendocrine carcinoma (NEC) of non-lung origin and neuroendocrine tumors (NETs) of the gastroenteropancreatic or bronchopulmonary system. Symptomatic brain metastases are associated with dismal prognosis, so early detection and treatment could be advisable.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Rinke A

Authors: Rinke A, Müller D, König A, Arnold R, Gress T,

Keywords: brain metastases, NET, NEC, prognosis,

#134 Gastrointestinal neuroendocrine tumors: tumor characteristics and long-term clinical outcome in the German NET registry

Introduction: Prognosis of neuroendocrine tumors (NETs) has been difficult to predict due to heterogenous tumor biology, various classification systems, and lack of reliable and recent data due to the rarity of these tumors.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Maasberg S

Authors: Maasberg S, König A, Rinke A, Anlauf M, Isermann B,

Keywords: gastrointestinal, epidemiology, overall survival, WHO-classification, grading,

#110 Slug represents an important regulator of E-cadherin expression in neuroendocrine tumor cells of the pancreas

Introduction: Neuroendocrine tumors of the pancreas form an inhomogenous group of epithelial neoplasms. They differ from other types of pancreatic cancers by showing an extended survival of patients, which is due to a mostly slow proliferation rate of the tumor. However, some of these neuroendocrine tumors are characterized by an early onset of metastases, which cannot be predicted by any available method. The epithelial to mesenchymal transition (EMT) represents a central part of cell migration and metastasis. During EMT, cells loosen their cellular contacts, leave the tissue, and become migrating single cells. One of the integral compounds of cell adhesion represents the E-cadherin adhesion module, which contains mostly E-cadherin and several catenins. A loss of this adhesion module is associated with tumor progression, migration and metastasis in many types of cancer.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: König A

Authors: König A, Reutlinger K, Ellenrieder V, Gress T, Fendrich V,

Keywords: neuroendocrine tumor of the pancreas, E-cadherin, Slug, cell adhesion,

#109 Transarterial chemoebolization (TACE) of liver metastases derived from neuroendocrine tumors is an effective treatment only in patients with low or mediate hepatic tumor burden

Introduction: The onset of metastases in patients with neuroendocrine tumors of the gastrointestinal tract (GEP-NET) represents a negative predictor of survival and tumor-associated complications. Thereby, most of these patients develop liver metastases during their disease. Transarterial chemoembolization (TACE) has been shown before to be an effective and safe treatment of liver metastases. However, the optimal time point in treatment of liver metastases has not yet been determined, especially in patients with non-functional GEP-NET.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Rinke A, König A, Müller D, König U, Gress T,

Keywords: neuroendocrine tumor, chemoembolization, tumor burden,