Abstract Library

#3668 Factors contributing to tumor shrinkage after peptide receptor radionuclide therapy in patients with unresectable neuroendocrine tumors

Introduction: Peptide receptor activation therapy (PRRT) is a promising treatment option for metastatic neuroendocrine tumors (NETs). However, predicting tumor shrinkage before treatment is challenging.

Conference:

Presenting Author:

Authors: Noritoshi K, Sho H, Wild D, Kaul F, Motokazu S,

Keywords: lesion-based analysis, neuroendocrine tumor, peptide receptor radionuclide therapy,

#3188 mTOR pathway inhibitors differently effect proliferation and gene expression in pancreatic and pulmonary NET cell lines

Introduction: The mammalian target of rapamycin (mTOR) is part of the PI3K/Akt/mTOR signalling pathway which has a central role in the oncogenesis of neuroendocrine tumors (NETs). Everolimus (EVE), an mTOR inhibitor, has shown effective in delaying progression of advanced NETs, but with a limited long-term efficacy, possibly due to a compensatory activation of the PI3K/AKT signalling. BYL719, a PI3K inhibitor, was shown to inhibit growth of several NET cell line models.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Mor-Cohen R

Authors: Mor-Cohen R, Braiman N, Tirosh A,

Keywords: NET cell lines, PI3K/Akt/mTOR signalling, Wnt signalling, everolimus, BYL719,

#2886 Risk Factors for Short Recurrence-Free Survivals after Resection of PanNET Liver Metastasis: Single Institutional Analysis

Introduction: Although the treatment of PanNEN has improved survivals with development of pharmacotherapy recently, surgery is the first choice if curative resection is expected to be achieved. However, most of the patients undergo recurrence after resection of the liver metastasis even after curative resection. Therefore, it is important to identify who gains longer RFS by resection.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Masui T, Anazawa T, Nagai K, Sato A, Nakano K,

Keywords: liver metastasis, PanNEN, resection, indication,

#2203 A Case of Rectal Abscess Emerged Immediately after Starting Chemotherapy with Everolimus and Required Surgical Drainage

Introduction: Everolimus is widely used for unresectable panNET. For its efficacy as an immunosuppressant, infectious adverse events are well-known.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Nakano K, Masui T, Yogo A, Uchida Y, Sato A,

Keywords: everolimus, infection, abscess, rectal abscess, surgery, drainage,

#2191 Endocrine Paraneoplastic Syndromes in Patients with Neuroendocrine Neoplasms

Introduction: Endocrine paraneoplastic syndromes (ePNS) result from production of bioactive substances from tumours not related to their expected tissue of origin. Neuroendocrine neoplasms (NENs) have been associated with ectopic secretion of several hormones, but the prevalence of ePNS has only been described in a small number of studies.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Chatzellis E, Alexandraki K, Angelousi A, Tsoli M, Kaltsatou M,

Keywords: paraneoplastic syndromes, neuroendocrine neoplasms, ectopic secretion,