Abstract Library

#4588 Spatial transcriptomics identifies Wnt signalling in multifocal ileal neuroendocrine tumours

Introduction: Ileal neuroendocrine tumours (i-NETs) often present with multiple primary tumours (>30-40%). Recent studies showed no shared somatic mutations in multiple primary tumours, highlighting the need to examine the tumour microenvironment in tumorigenesis. The Wnt signalling pathway is crucial for organ stem cell regulation. While the Wnt/β-catenin pathway influences prostate and pancreatic NET/Cs, its role in i-NETs remains unclear.

Conference:

Presenting Author:

Authors: Yogo A, Akanuma N, Kim G, Thirlwell C, Mäkinen N,

Keywords: Wnt Signalling, Spatial Transcriptomics,

#3643 Effect of resection timing as part of multidisciplinary treatment for pancreatic NEN liver metastases

Introduction: Liver metastases are treated by resection if radical resection is possible as a part of multidisciplinary treatment along with pharmacotherapy and TACE.

Conference:

Presenting Author:

Authors: Masui T, Nagai K, Anazawa T, Kasai Y, Yogo A,

Keywords: liver metastasis, multidisciplinary treatment,

#2951 Analysis of Discordance between Biopsy Grade and Surgical Pathology Grade in Resected PanNEN Patients

Introduction: In PanNEN cases, treatment strategies are decided by tumor localization, volume and grade. In unresectable or metastatic cases, tumor grade is determined by biopsy specimen obtained from EUS-FNA and diagnostic accuracy of biopsy according to WHO classification 2017 is important for decision making of treatment.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Nakano K, Masui T, Yogo A, Uchida Y, Nagai K,

Keywords: PanNEN, WHO classification 2017, EUS-FNA, Ki-67, biopsy, surgical pathology, discordance,

#2203 A Case of Rectal Abscess Emerged Immediately after Starting Chemotherapy with Everolimus and Required Surgical Drainage

Introduction: Everolimus is widely used for unresectable panNET. For its efficacy as an immunosuppressant, infectious adverse events are well-known.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Nakano K, Masui T, Yogo A, Uchida Y, Sato A,

Keywords: everolimus, infection, abscess, rectal abscess, surgery, drainage,