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Analysis of Discordance between Biopsy Grade and Surgical Pathology Grade in Resected PanNEN Patients


Introduction: In PanNEN cases, treatment strategies are decided by tumor localization, volume and grade. In unresectable or metastatic cases, tumor grade is determined by biopsy specimen obtained from EUS-FNA and diagnostic accuracy of biopsy according to WHO classification 2017 is important for decision making of treatment.

Aim(s): In this study, we analyzed EUS-FNA-based Ki-67 and compared to that of surgical resection specimen to estimate the factors influencing accuracy of the EUS-FNA-based Ki-67.

Materials and methods: We performed a single-institutional, retrospective review. Patients underwent resection of primary PanNEN lesions at our institution from Apr. 2011 to Sep. 2019 are included. In 53 patients underwent surgical resection of the primary PanNEN lesions, 43 patients (81%) underwent pre-operational biopsy.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Nakano K, Masui T, Yogo A, Uchida Y, Nagai K,

Keywords: PanNEN, WHO classification 2017, EUS-FNA, Ki-67, biopsy, surgical pathology, discordance,

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