Abstract Library

#2705 Increased Autophagy/Mitophagy Levels in Pancreatic Neuroendocrine Neoplasms

Introduction: Autophagy and mitophagy are key homeostatic machineries linked to cancer development and drug resistance.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Daskalakis K, Alexandraki K, Kloukina I, Kassi E, Felekouras E,

Keywords: Pancreatic Neuroendocrine Tumors, Autophagy, Mitophagy,

#2073 Epigenetic Modulation of Autophagy in Pancreatic Spheroid Cells

Introduction: Pancreatic neuroendocrine malignancy is rising up in the last decade. Despite surgical resection and palliative therapy, an effective therapy has not been developed yet.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Matrood S

Authors: Matrood S, Wissniowski T, Wiese D, Gress T, Bartsch D,

Keywords: spheroid, autophagy, pancreatic neuroendocrine tumor, AMPK-alpha, stellate cells,

#2030 Autophagy Process in Pancreatic Neuroendocrine Tumor Cells

Introduction: Pancreatic neuroendocrine malignancy is rising up in the last decade. Despite surgical resection and palliative therapy, an effective therapy has not been developed yet.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Matrood S

Authors: Matrood S, Wissniowski T, Wiese D, Buchholz M, Gress T,

Keywords: autophagy, pancreatic neuroendocrine tumor, AMPK-alpha,

#1999 Study of Cell Cycle Protein Expression Pattern in Bronchial Carcinoids: A New Potential Target for Medical Therapy?

Introduction: Bronchial Carcinoids (BCs) are rare neuroendocrine neoplasms arising from respiratory epithelium. The only effective treatment option is surgery, but its efficacy is frequently limited by metastatic spread. Everolimus prolongs progression free survival but patients may develop resistance. Previous studies demonstrated that Everolimus reduces viability of NCI-H720 cells (Atypical Carcinoid) but not of NCI-H727 cells (Typical Carcinoid). Everolimus decreases Ciclyn D1 protein levels in both cell lines but NCI-H727 cells survive, indicating a derangement in cell cycle control.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Bresciani G, Riva E, Ambrosio M, Zatelli M,

Keywords: bronchial carcinoids, cell cycle, cyclins, cdks, target therapy, everolimus, dinaciclib, palbociclib,

#1637 The Effect of the Autophagy Inhibitor Chloroquine (CQ), Alone or in Combination with mTOR Inhibitors, on Neuroendocrine Tumor (NET) Growth and Metastatic Spread in Mouse Models

Introduction: mTOR inhibitors (mTORi) such as RAD001 demonstrated promising anti-cancer effect in NETs. Autophagy, a cell survival mechanism, is activated by mTORi. We have recently shown in the human NET cell line BON1 that autophagy is essential for cell survival. Treatment with CQ alone or together with mTORi robustly inhibited cell proliferation and survival, suggesting that treatment with CQ may potentiate the anti-tumorigenic effects of mTORi.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Avniel-Polak S

Authors: Avniel-Polak S, Leibowitz G, Gross D, Grozinsky-Glasberg S,

Keywords: autophagy, mTORi, NET,