Abstract Library

#2249 Pasireotide as a Possible Tool for the Control of Refractory Hyperinsulinemic Hypoglycemia from Malignant Insulinoma

Introduction: The control of hypoglycemic hyperinsulinemic syndrome from malignant insulinoma is challenging because it is often refractory to diazoxide and somatostatin analogues (SA). Everolimus can have side effects that can limit its use. Pasireotide, a multi-receptor-targeted SA with a high binding affinity to SSTR1 and SSTR5, exhibits a strong inhibitory effect of insulin secretion.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Davi' M

Authors: Zambon G, Cosaro E, Cingarlini S, Trombetta M, Landoni L,

Keywords: pasireotide, malignant insulinoma, hypoglycemia,

#2192 Immunohistochemical Profiles in 81 Patients with Resected Insulinomas

Introduction: Ninety percent of insulinomas are benign. However, there are no well-defined immunohistochemical criteria that can distinguish a benign from a malignant insulinoma

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Andreassen M

Authors: Andreassen M, Ilett E, Slater E, Wiese D, Hansen C,

Keywords: insulinoma, malignancy, immunohistochemistry,

#2124 A Case Report of a Malignant Insulinoma

Introduction: Despite rare (1-2% of pancreatic tumors/PT), insulinomas are the most common functional pNET. The diagnosis is established by demonstrating inappropriately high serum insulin levels during a spontaneous or induced episode of hypoglycemia.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Zoumblios C, Tegos T, Kyriakopoulos G, Argyrakos T, Alevizopoulos N,

Keywords: malignant, insulinoma,

#1870 Detection of Metastatic Insulinoma with 68Ga-NODAGA-Exendin-4 PET/CT in a Young Child – A Case Report

Introduction: Malignant insulinomas are extremely rare in children. Localizing metastases of insulinoma is challenging. Imaging modalities like CT and MRI show limited results. Somatostatin-receptor (SSTR) imaging (SRS) performs better. However, a subgroup of malignant insulinoma lack SSRT-2 and can, therefore, not be localized using SRS. We propose that in these cases GLP-1R imaging, using the stable GLP-1 analog exendin, could play an important role.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Boss M

Authors: Boss M, de Herder W, Hussain K, Shah P, Brom M,

Keywords: Metastatic insulinoma, GLP-1R, PET, exendin,

#1390 Ectopic Malignant Insulinoma with Multiple Liver Metastases: A Case Report

Introduction: Malignant insulinoma arising from ectopic pancreas is very rare.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Liu Q

Authors: Liu Q, Luo J, Li C, Zhu Z, Tan H,

Keywords: ectopic malignant insulinoma, octreotide, everolimus, 68Ga-exendin-4 PET/CT,