Abstract Library

#4623 [68Ga]Ga-DOTA-Exendin-4 PET/CT for the localisation of insulinoma: Results of an international, dual-centre, retrospective, open-label real-world imaging study

Introduction: Benign insulinomas are the main cause of endogenous hyperinsulinemic hypoglycaemia (EHH) in adults, with surgery as the only cure. Pancreas-preserving procedures are preferred, making precise localisation crucial. Recent studies indicate that GLP-1R imaging, such as [68Ga]Ga-DOTA-exendin-4 (68Ga-Ex4) PET/CT, outperforms conventional imaging in identifying insulinomas.

Conference:

Presenting Author: Fricke J

Authors: Fricke J, Laubner K, Schildmeijer M, Menz L, Christ E,

Keywords: GLP1-Receptor PET/CT, Insulinoma, nesidioblatosis, endogenous hyperinsulinemic hypoglycaemia, real-life data,

#4387 Exenatide-test for diagnosing endogenous hyperinsulinemic hypoglycaemia: A randomised placebo-controlled cross-over proof-of-principle study – FAST study

Introduction: The gold standard to diagnose endogenous hyperinsulinemic hypoglycaemia (EHH) is the fasting test which is cumbersome and incurs high costs. In the setting of radio-labelled 68Ga-exendin-4 PET/CT in patients with EHH (to localise insulinoma), we unexpectedly observed clinically relevant hypoglycaemia following administration of the tracer, which does usually not occur after GLP-1 agonist therapy in type 2 diabetic patients and in healthy subjects.

Conference:

Presenting Author: Christ E

Authors: Hepprich M, Romberg C, Fricke J, Freitag M, Mudry J,

Keywords: endogenous hyperinsulinemic hypoglycaemia, insulinoma, Exendin, Fasting test,

#4327 Metastatic non-functional pancreatic neuroendocrine tumour with transformation to insulinoma shown on 68Ga-Exendin-4 PET/CT

Introduction: 68Ga-exendin-4 PET/CT imaging has been utilised for benign insulinomas. However, some reports demonstrated the absence of GLP-1R expression of malignant insulinomas.

Conference:

Presenting Author:

Authors: Gao J, Xu J, Liang Y, Chen J, Song S,

Keywords: pancreatic neuroendocrine tumour, PET/CT, insulinoma, 68Ga-exendin-4,

#4323 The value of 68Ga-Exendin-4 PET/CT for benign and metastatic insulinoma

Introduction: Insulinoma is the most common functional pancreatic neuroendocrine tumour which is difficult to locate by conventional imaging. 68Ga-exendin-4 PET/CT is a promising technique for detecting benign insulinomas but is not definite for metastatic insulinomas.

Conference:

Presenting Author: Xu J

Authors: Xu J, Liang Y, Huang D, Chen J, Song S,

Keywords: insulinoma, 68Ga-exendin-4, PET/CT,

#3947 Heterogeneity of multiple pancreatic neuroendocrine tumors identified by 68Ga-DOTANOC and 68Ga-exendin-4 PET/CT in a patient with endogenous hyperinsulinemic hypoglycaemia and multiple endocrine neoplasia 1

Introduction: Insulinomas are the most frequent functional neuroendocrine tumors of pancreas cause endogenous hyperinsulinemic hypoglycemia (EHH). In about 10% cases, insulinomas are associated with multiple endocrine neoplasia 1 (MEN1).

Conference:

Presenting Author: Xu J

Authors: Xu X, Xu X, Liang Y, Zhang M, Chen J,

Keywords: MEN1, insulinoma, 68Ga-DOTANOC, 68Ga-exendin-4, PET/CT,