Metastatic non-functional pancreatic neuroendocrine tumour with transformation to insulinoma shown on 68Ga-Exendin-4 PET/CT

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Introduction: 68Ga-exendin-4 PET/CT imaging has been utilised for benign insulinomas. However, some reports demonstrated the absence of GLP-1R expression of malignant insulinomas.

Aim(s): We present a case of a non-functional metastatic pancreatic neuroendocrine tumour that transformed into an insulinoma primely demonstrated by 68Ga-Exendin-4 PET/CT.

Materials and methods: A 52-year-old man was pathologically diagnosed with a pancreatic neuroendocrine tumour (pNET) and synchronous liver metastasis by debulking surgery 2 years ago. The patient showed recurrent severe hypoglycaemia recently after receiving multiple lines of treatment. 68Ga-DOTANOC and 68Ga-exendin-4 PET/CT were used to assess the metastatic lesions of the whole body due to the tumour progression and uncontrolled hypoglycaemia symptoms.

Conference:

Presenting Author:

Authors: Gao J, Xu J, Liang Y, Chen J, Song S,

Keywords: pancreatic neuroendocrine tumour, PET/CT, insulinoma, 68Ga-exendin-4,