Abstract Library
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Introduction: Malignant insulinomas are extremely rare in children. Localizing metastases of insulinoma is challenging. Imaging modalities like CT and MRI show limited results. Somatostatin-receptor (SSTR) imaging (SRS) performs better. However, a subgroup of malignant insulinoma lack SSRT-2 and can, therefore, not be localized using SRS. We propose that in these cases GLP-1R imaging, using the stable GLP-1 analog exendin, could play an important role.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Boss M
Authors: Boss M, de Herder W, Hussain K, Shah P, Brom M,
Keywords: Metastatic insulinoma, GLP-1R, PET, exendin,
Introduction: Insulinomas are usually small, single tumors. Precise preoperative localization of the tumor is essential. Imaging techniques like CT and MRI have limited sensitivity and also somatostatin receptor (SSTR) imaging is not specific. Exendin specifically binds the GLP-1 receptor (GLP-1R), which is markedly upregulated in insulinomas. 68Ga-DOTA-exendin-4 PET/CT has been shown to be feasible in detecting insulinomas. Replacing DOTA by NODAGA ensures higher specific activities. We propose 68Ga-NODAGA-exendin-4 PET/CT as a promising new method for improved localization of insulinomas.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Boss M
Authors: Boss M, Buitinga M, Brom M, Wild D, Prasad V,
Keywords: Insulinoma, PET, exendin,
#1055 Neuroendocrine Pancreatic Tumor Associated with a Cerebral Neurofibroma. A Case Report.
Introduction: Neuroendocrine pancreatic tumors (pNET) are rare in young patients. They usually occur in the setting of genetic syndromes.
Conference: 12th Annual ENETSConcerence (2015)
Presenting Author: Lico V
Authors: Moletta L, Milanetto A, Lico V, Farinati F, Alaggio R,
Keywords: pnet, cerebral neurofibroma, nf-1,
Introduction: We describe two cases of neuroendocrine tumors (NETs) in patients with neurofibromatosis type 1 (NF1) associated with gastrointestinal stromal tumors (GISTs).
Conference: 11th Annual ENETSConcerence (2014)
Presenting Author: Zerbi A
Authors: Ridolfi C, Gavazzi F, Spaggiari P, Carnaghi C, Lania A,
Keywords: pancreatic and ampullary neuroendocrine tumor, neurofibromatosis-1, GIST,
Introduction: Neurofibromatosis type 1 (NF1) is a rare inherited disorder associated with cutaneous lesions and neoplasms in the nervous and gastroenteropancreatic systems, including periampullary NETs. NF1-coded protein, neurofibromin, is a tumor suppressor that negatively regulates the mammalian target of rapamycin (mTOR). Preclinical in vitro and in vivo studies demonstrated a constitutive activation of mTOR pathway associated with significant antineoplastic effects of mTOR inhibitors in NF1-related glial tumor models.
Conference: 10th Annual ENETSConcerence (2013)
Presenting Author: Razzore P
Authors: Razzore P, Volante M, Russolillo N, Motta M, Lacidogna G,
Keywords: NF1, periampullar NETs, mTOR ,