#1870
Detection of Metastatic Insulinoma with 68Ga-NODAGA-Exendin-4 PET/CT in a Young Child – A Case Report
Introduction:
Malignant insulinomas are extremely rare in children. Localizing metastases of insulinoma is challenging. Imaging modalities like CT and MRI show limited results. Somatostatin-receptor (SSTR) imaging (SRS) performs better. However, a subgroup of malignant insulinoma lack SSRT-2 and can, therefore, not be localized using SRS. We propose that in these cases GLP-1R imaging, using the stable GLP-1 analog exendin, could play an important role.
Conference:
14th Annual ENETSConcerence (2017)
Presenting Author:
Boss M
Authors:
Boss M,
de Herder W,
Hussain K,
Shah P,
Brom M,
Keywords:
Metastatic insulinoma,
GLP-1R,
PET,
exendin,
#1709
68Ga-NODAGA-exendin-4 PET/CT for the Localization of Insulinomas: Preliminary Data from a Prospective Multicenter Imaging Study.
Introduction:
Insulinomas are usually small, single tumors. Precise preoperative localization of the tumor is essential. Imaging techniques like CT and MRI have limited sensitivity and also somatostatin receptor (SSTR) imaging is not specific. Exendin specifically binds the GLP-1 receptor (GLP-1R), which is markedly upregulated in insulinomas. 68Ga-DOTA-exendin-4 PET/CT has been shown to be feasible in detecting insulinomas. Replacing DOTA by NODAGA ensures higher specific activities. We propose 68Ga-NODAGA-exendin-4 PET/CT as a promising new method for improved localization of insulinomas.
Conference:
14th Annual ENETSConcerence (2017)
Presenting Author:
Boss M
Authors:
Boss M,
Buitinga M,
Brom M,
Wild D,
Prasad V,
Keywords:
Insulinoma,
PET,
exendin,
