The role of fibrosis markers in predicting decline in renal function in patients undergoing PRRT

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Introduction: Renal impairment due to renal fibrosis is a potential side effect in NET-patients undergoing Peptide Receptor Radionuclide Therapy (PRRT). Fibrosis markers are small collagen formation - and degradation fragments that are measurable in circulation at very early stages of fibrosis formation.

Aim(s): We aimed to investigate fibrosis markers as predictive markers for decline in renal function in NET-patients undergoing PRRT.

Materials and methods: Eligible patients were NET-patients referred to PRRT treatment. For measurements of three different fibrosis markers (PRO-C3, PRO-C6, and C3M), blood- and urine samples were drawn before initiation of PRRT and repeated after each treatment. A kidney function test was done before initiation of PRRT and three months after end of treatment and if possible repeated regularly after end of treatment.

Conference:

Presenting Author: Lau T

Authors: Lau T, Bossen L, Rasmussen D, Karsdal M, Genovese F,

Keywords: PRRT, Biomarker, Fibrosis Marker,