Abstract Library

#4539 Single-nucleus profiling of the tumour microenvironment in SI-NET patients

Introduction: Small intestinal neuroendocrine tumours (SI-NETs) are frequently present as multiple synchronous primary tumours in the small bowel. They are thought to arise from enterochromaffin (EC) cells in the gut, which account for less than 1% of the intestinal epithelium. Previously reported lack of shared somatic driver alterations in SI-NETs suggests that other, non-genetic mechanisms are likely involved in their tumorigenesis.

Conference:

Presenting Author: Mäkinen N

Authors: Mäkinen N, Kasai Y, Kim G, Thirlwell C, Nakakura E,

Keywords: small intestinal NET, tumour microenvironment, single-nucleus sequencing,

#4248 Tryptophan pathway metabolites as prognostic biomarkers of recurrent disease in curatively operated neuroendocrine tumor patients

Introduction: The majority of NET patients experience recurrent disease after curative surgery. There is a need for prognostic biomarkers in this patient group.

Conference:

Presenting Author: Johansen S

Authors: Johansen S, Hansen T, Goll R, Florholmen J,

Keywords: Plasma Tryptophan Metabolites, Prognostic Biomarker, Recurrent Disease after Curative Surgery,

#4166 Characterising the tumor microenvironment of multifocal small intestinal NETs

Introduction: Small intestinal neuroendocrine tumors (SI-NETs) are thought to arise from enterochromaffin cells of the gut, often with multiple synchronous primary tumors. Recently, we showed that synchronous primary tumors from the same SI-NET patient display distinct somatic mutational profiles, suggesting that these tumors originate independently, despite few clear driver mutations. Thus, new mechanistic insights into multifocal SI-NETs are urgently needed.

Conference:

Presenting Author:

Authors: Mäkinen N, Lee I, Dohlman A, Gao T, Zhang Z,

Keywords: small intestinal NET, tumor microenvironment, tumor microbiome,

#3753 The additive value of F-18 fluorodeoxyglucose PET imaging in grade 1 gastroenteropancreatic neuroendocrine tumors (GEP-NETs)

Introduction: Grade 1 gastroenteropancreatic NETs (GEP-NETs) exhibit better prognosis compared to Grade 2-3 tumors. High uptake in 68Ga-DOTATOC PET imaging is commonly seen in well-differentiated tumors whereas uptake in F-18 FDG PET imaging is associated with aggressive behaviour.

Conference:

Presenting Author:

Authors: Liotsou T, Metaxas M, Georgakopoulos A, Tsoli M, Panagaki M,

Keywords: F-18 FDG-PET, grade 1 GEP-NET, prognosis,

#3574 Multiple Endocrine Neoplasia type 1 (MEN1): A series of cases in an oncology department

Introduction: Multiple Endocrine Neoplasia type 1 is an autosomal dominant disorder characterized by parathyroid, pancreatic islet and pituitary tumors. Early diagnosis should be achieved in patients with MEN1.

Conference:

Presenting Author: Tsoukalas N

Authors: Tsoukalas N, Arvanitou E, Gkikas K, Malliopoulos D, Chatzelis E,

Keywords: Multiple Endocrine Neoplasia type 1, MEN1 syndrome, MEN1 gene, Neuroendocrine tumor, Multidisciplinary approach,