Abstract Library

#4453 Multiple sporadic neuroendocrine tumours: A diagnostic challenge

Introduction: Neuroendocrine tumours (NETs) show substantial clinical and histological heterogeneity. The presence of multiple primary NETs represents a diagnostic and therapeutic challenge as clinicians have to differentiate between primary and metastatic NETs.

Conference:

Presenting Author: Tsoli M

Authors: Tsoli M, Koumarianou A, Panagaki M, Ioannidou K, Kyriakopoulos G,

Keywords: neuroendocrine tumour, double primary, immunohistochemistry,

#4417 Efficacy of immune checkpoint inhibitors (ICI) in patients with advanced pancreatic NETs displaying high TMB and MMR alterations following treatment with alkylating agents

Introduction: Alkylating chemotherapy (ALK) is frequently used in patients with PanNETs. It may favour grade progression and acquisition of a hypermutator phenotype associated with frequent alterations of the MMR genes, suggesting a potential benefit of ICI.

Conference:

Presenting Author:

Authors: de Mestier L, Apostolidis L, Koumarianou A, Hernando Cubero J, Riechelmann R,

Keywords: immune checkpoint inhibitor, immunotherapy, hypermutagenicity, alkylating agents, tumour mutational burden, mismatch repair,

#4114 Delays in the dosing administration of PRRT in advanced neuroendocrine tumors – Is there an adverse impact?

Introduction: Peptide receptor radionuclide therapy (PRRT) has emerged as a major therapeutic component in the overall management of advanced neuroendocrine tumors (NETs). In Greece, the treatment has been performed for several years, however because of reimbursement issues, especially during the financial crisis in Greece, there is usually a delay between the administered doses beyond the recommended 6-8 weeks interval.

Conference:

Presenting Author:

Authors: Georgakopoulos A, Tsoli M, Koumarianou A, Papadopoulou N, Panagaki M,

Keywords: PRRT, Progression-free survival, overall survival,

#3751 Grade 2 gastric carcinoids type 1 – Not always an indolent disease

Introduction: Gastric carcinoids type 1 (GC1) are increasingly recognized and are usually well-differentiated grade 1 neoplasms. However, rare cases of metastatic spread and adverse prognosis have been described in the literature.

Conference:

Presenting Author:

Authors: Tsoli M, Koumarianou A, Karapanagioti A, Daskalakis K, Panagaki M,

Keywords: gastric carcinoid, grade 2,

#3545 Virchow's node metastasis from small intestinal neuroendocrine neoplasms: A bi-center cohort study

Introduction: Small Intestinal Neuroendocrine Neoplasms (SI-NENs) may rarely metastasize to the left supraclavicular lymph nodes, also known as Virchow’s node metastasis (VM).

Conference:

Presenting Author: Wedin M

Authors: Wedin M, Tsoli M, Wallin G, Janson E, Koumarianou A,

Keywords: Virchow's node metastasis, Small intestinal NEN,