Transcription Factor Signature in Pancreatic and Duodenal Neuroendocrine Neoplasms

#171

Introduction: We recently identified ISL1 as a marker for pancreatic neuroendocrine neoplasms (P-NENs). ISL1 as well as PDX1, CDX2 and NGN3 are transcription factors (TF) involved in pancreato-duodenal development.

Aim(s): We studied these four main TFs in hormonally characterized P- and duodenal (D)-NENs to better understand their expression, site and hormonal specificity.

Materials and methods: A series of 49 P-NENs (35) and D-NENs (14) were immunolabeled with antibodies to insulin, glucagon, somatostatin, pancreatic polypeptide (PP), gastrin, serotonin, calcitonin, ISL1, PDX1, NGN3, CDX2 and Ki-67. The pattern of TFs was examined and correlated to the tumor hormonal profile, functionality, location, grade, size and metastatic status.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Hermann G, Klöppel G, Konukiewitz B, Schmitt A, Perren A,

Keywords: neuroendocrine, neoplasm, pancreas, duodenum, transcription factors, isl1, pdx1, ngn3, cdx2, ihc,