Transcription Factor Signature in Pancreatic and Duodenal Neuroendocrine Neoplasms Abstract #171

Introduction: We recently identified ISL1 as a marker for pancreatic neuroendocrine neoplasms (P-NENs). ISL1 as well as PDX1, CDX2 and NGN3 are transcription factors (TF) involved in pancreato-duodenal development.
Aim(s): We studied these four main TFs in hormonally characterized P- and duodenal (D)-NENs to better understand their expression, site and hormonal specificity.
Materials and methods: A series of 49 P-NENs (35) and D-NENs (14) were immunolabeled with antibodies to insulin, glucagon, somatostatin, pancreatic polypeptide (PP), gastrin, serotonin, calcitonin, ISL1, PDX1, NGN3, CDX2 and Ki-67. The pattern of TFs was examined and correlated to the tumor hormonal profile, functionality, location, grade, size and metastatic status.
Conference: 8th Annual ENETS Conference (2011)
Category: Basic
Presenting Author: Gratiana Hermann

To read results and conclusion, please login ...

Further abstracts you may be interested in

#2689 Correlation between Immunohistochemical Markers Expression and Lymph Node Metastasis in Gastroenteropancreatic Neuroendocrine Neoplasms: A Nation-Wide 10-Year Retrospective Clinical Epidemiological Study in China
Introduction: Previous research on the correlation between different pathological features and the development of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) is rare in China.
Conference: 17th Annual ENETS Conference 2020 (2020)
Category: Epidemiology/Natural history/Prognosis - Registries, nationwide and regional surveys
Presenting Author: Huan Yang
Authors: Yang H, Shi S, Zhang S, Ji Y, ...
#2768 Risk Factors of the Distant Metastasis in Gastric Neuroendocrine Neoplasms: A 10-Year Retrospective Study in China
Introduction: Research on the risk factors of metastasis of gastric neuroendocrine neoplasms (g-NENs) is rare in China.
Conference: 17th Annual ENETS Conference 2020 (2020)
Category: Epidemiology/Natural history/Prognosis - Registries, nationwide and regional surveys
Presenting Author: Huijiao Yan
Authors: Yan H, Yang H, Zhang S, Chi Y, ...
#2784 Predictive Factors of Tumor Recurrence after Radical Surgery for Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NENs): Identification of High-Risk Subgroups
Introduction: There is no proven role for adjuvant medical therapy after curative surgery (R0) for GEP-NENs.
Conference: 17th Annual ENETS Conference 2020 (2020)
Category: Epidemiology/Natural history/Prognosis - Registries, nationwide and regional surveys
Presenting Author: Dr Roberta Elisa Rossi
#2790 Trends of Incidence and Prognosis of Gastric Neuroendocrine Neoplasms - A Study Based on SEER and Our Multicenter Research
Introduction: The incidence of gastric neuroendocrine neoplasms (GNENs) is increasing but we still lack effective tools for risk stratification so far.
Conference: 17th Annual ENETS Conference 2020 (2020)
Category: Epidemiology/Natural history/Prognosis - Registries, nationwide and regional surveys
Presenting Author: Ping Hu
Authors: Hu P, Bai J, Liu M, Tang Q, ...
#2831 Immunohistochemical Profile of Digestive Neuroendocrine Neoplasms: A Retrospective Analysis in a Single Algerian Institution
Introduction: Neuroendocrine Noplasms (NEN) are rare tumours, but their incidence is clearly increasing in our country due to the improvement of diagnostic means, in particular the generalization of immunohistochemical techniques. The digestive location represents more than 70% of the cases. The anatomopathological study enables to classify the NEN in different prognostic grades according to the degree of differentiation, mitotic index and Ki67.
Conference: 17th Annual ENETS Conference 2020 (2020)
Category: Epidemiology/Natural history/Prognosis - Registries, nationwide and regional surveys
Presenting Author: Djihed Belabdi