Abstract Library

#3058 Diagnosis and Assessment of Effectiveness of Surgical Resection of Small Bowel Neuroendocrine Tumours: The Roles of Circulating MicroRNAs

Introduction: MicroRNAs (miRNA) are small noncoding RNA molecules implicated in the pathophysiology of myriad neoplasms. Clinically useful biomarkers are needed in SB NET to ascertain disease aggressiveness, select treatment strategy, detect early recurrence and monitor response.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Clift A

Authors: Malczewska A, Frampton A, Prado M, Ameri S, Dabrowska A,

Keywords: neuroendocrine, small bowel, intestine, microRNA, biomarker,

#2840 A Real-World Study of Patients with Carcinoid Syndrome at King’s College Hospital on Long-Term Telotristat Therapy

Introduction: Telotristat ethyl is a tryptophan hydroxylase inhibitor that has been shown to be effective against symptoms of carcinoid syndrome refractory to standard somatostatin analogue therapy by directly inhibiting serotonin production. While clinical trials have established short-term efficacy of the drug, we report an exploratory real-world study of 15 patients with metastatic neuroendocrine tumours on long-term Telotristat (median duration=8 months).

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Hota S, Cananea E, Martin W, Clement D, Solis B,

Keywords: Neuroendocrine tumours, carcinoid syndrome, telotristat ethyl,

#1816 Multivisceral Transplantation and Vascularised Sentinel Forearm Flap for a Metastatic Small Bowel Neuroendocrine Tumour: Update on Follow-Up

Introduction: We previously reported the first documented case of a novel approach in a patient with extensive mesenteric metastases from a small bowel neuroendocrine tumour (SBNET): this combined multivisceral transplantation (MVT) and a vascularised sentinel forearm flap (VSFF) from the same donor.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Frilling A

Authors: Frilling A, Giele H, Vrakas G, Reddy S, Macedo R,

Keywords: small bowel neuroendocrine tumour, multivisceral transplantation, forearm flap, follow-up,

#1815 MicroRNAs Associated with Small Bowel Neuroendocrine Tumours and Their Metastases

Introduction: Novel molecular analytes are needed in small bowel NETs (SBNETs) to better determine disease aggressiveness and predict treatment response.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Frampton A

Authors: Frampton A, Miller H, Malczewska A, Ottaviani S, Stronach E,

Keywords: miRNA, small bowel neuroendocrine tumour,

#1746 Clinical Outcomes in Small Neuroendocrine Tumours Treated with Intestinal Surgery in Tertiary Centre

Introduction: Patients with Small Bowel Neuroendocrine Tumours (SBNET) may require small bowel surgery either as an emergency or electively.Robust data from Tertiary Referral Centres (TRC) are lacking.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Demetriou G

Authors: Demetriou G, Crawford A, Guarino S, Ogunbiyi O, Varcada M,

Keywords: NET, intestinal surgery,