Abstract Library

#1490 Even Malignant Appendiceal Neuroendocrine Tumors Exhibit No Recurrent Chromosomal Alterations

Introduction: Neuroendocrine tumors (NETs) of the midgut are located in the ileum (iNET), caecum or appendix (aNET). Despite of the similar origin, NETs of the ileum and the appendix behave remarkably different. iNETs show high malignant potential, which manifests with early lymph node or liver metastases. Genetically, the loss of chromosome 18 (Ch18) in 60-74% of cases is the most frequent alteration in iNETs. aNETs are often incidental findings, rarely show metastases, and no chromosomal alterations are known.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Sipos B

Authors: Nann D, Nieser M, Sperveslage J, Henopp T, Vokuhl C,

Keywords: NET,

#730 Loss of Chromosome 18 in Neuroendocrine Tumors of the Midgut

Introduction: The genetic alterations in neuroendocrine tumors (NET) of the midgut, in particular of the appendix (aNET), are poorly characterized. The most frequent chromosomal aberration in ileal NET (iNET) is the loss of one chromosome 18. The relevance of this alteration is unclear.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Henopp T, Brix J, Sperveslage J, Anlauf M, Petersen K,

Keywords: chr18,

#700 Comparative Expression Analysis of Chromosome 18 Related miRNAs in Ileal NET with and without Chr18 Loss

Introduction: MicroRNAs (miRs) play important roles in many kinds of biological processes. Because the (partial) loss of one chromosome 18 (Chr18) is a frequent event in ileal NETs (iNETs), we assessed the potential deregulation of miR-expression in these patients.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Sperveslage J

Authors: Hoffmeister M, Sperveslage J, Henopp T, Anlauf M, Petersen K,

Keywords: NET, mir-expression,

#565 Proliferative Activity is Not Associated with Tumor Aggressiveness in Ileal Neuroendocrine Tumors

Introduction: The accuracy of the new WHO grading system for neuroendocrine neoplasms has not yet been validated for ileal neuroendocrine tumors (iNETs).

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Henopp T, Sperveslage J, Anlauf M, Klöppel G, Neumayer B,

Keywords: ileal NET, proliferation, prognosis,

#564 Genetic Alterations in Glucagon Cell Adenomatosis

Introduction: Glucagon cell adenomatosis (GCA) was recently recognized by us as a multifocal neoplastic disease of the endocrine pancreas unrelated to MEN-1. Multiple micro- and a few macrotumors are found on the background of a hyperplasia of glucagon cells. The disease may cause unspecific abdominal symptoms and only rarely a glucagonoma syndrome. Recently a mutation in the glucagon receptor (GCGR) gene was described in one GCA patient.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Henopp T, Anlauf M, Biskup S, Klöppel G, Sipos B,

Keywords: glucagon,