Proliferative Activity is Not Associated with Tumor Aggressiveness in Ileal Neuroendocrine Tumors

#565

Introduction: The accuracy of the new WHO grading system for neuroendocrine neoplasms has not yet been validated for ileal neuroendocrine tumors (iNETs).

Aim(s): To analyse the proliferation rates in primary iNETS, lymph node and distant metastases in order to determine the prognostic power of grade 1 and grade 2 categories in the WHO 2010 classification.

Materials and methods: Sixty-four primary iNETs, 35 matched node metastases and 20 distant metastases were analysed for proliferation rate (Mib1, Phospho H3/Mitosis) using automated image analysis assessing the maximum (hot spot) and overall proliferative activity. Proliferation rates were compared in different prognostic relevant cohorts (N0M0, N1M0 and N1M1).

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Henopp T, Sperveslage J, Anlauf M, Klöppel G, Neumayer B,

Keywords: ileal NET, proliferation, prognosis,

To read the full abstract, please log into your ENETS Member account.