Abstract Library

#4502 Molecular analysis of non-functioning PanNETs of the alpha lineage reveals new subtypes and mechanisms of progression

Introduction: Most pancreatic neuroendocrine tumours (PanNETs) are non-functioning. Previously, we demonstrated that small, MEN1-only mutated α-like PanNETs can be distinguished from larger ADM (mutated in ATRX, DAXX and MEN1) PanNETs based on epigenetic profiles. ADM PanNETs have shorter disease-free survival and a higher relapse risk. However, their therapeutic responses vary, underscoring group heterogeneity. ADM PanNETs remain insufficiently characterised, with potential subtype-specific progression drivers with implications for treatment choice and clinical outcome.

Conference:

Presenting Author: Avanthay S

Authors: Avanthay S, Di Domenico A, Kirchner P, Bräutigam K, Chouchane A,

Keywords: pancreas, epigenetics, progression, metastasis, DAXX, ATRX, Pan NET,

#3745 Prediction of disease recurrence in patients after complete PanNET G2 resection

Introduction: The number of pancreatic neuroendocrine tumors (PanNETs) detected has been increasing over the past decade. Surgical resection is the only potentially curative treatment for PanNETs, but the risk factors for recurrence are not fully understood, which is of clinical value especially for G2 PanNETs due to their high heterogeneity.

Conference:

Presenting Author:

Authors: Opalinska M, Olearska H, Sowa-Staszczak A, Morawiec-Sławek K, Kurzyńska A,

Keywords: PanNET G2, recurrence risk, NET G2, surgery, PanNET,

#3353 Severe gastroduodenal ulceration following radioactive microspheres treatment in a woman with metastatic neuroendocrine tumor: A case report of paradoxical microsphere migration

Introduction: Incidence of liver metastasis (LM) in advanced NET is high and associated with poor prognosis. SIR-spheres for non-resectable LM in GEP NETs offers symptom regression and survival benefit. Complications are usually local given the SIR-spheres are delivered directly into the hepatic arteries and give off beta emitting radiation. Off target digression of microspheres to other tissues via hepaticoenteric arteries however can result in nearby organ damage.

Conference:

Presenting Author:

Authors: Smith A, Price T, Kitchener M, Trochsler M,

Keywords: SIR-spheres, microspheres, NET,

#3226 Immunohistochemical staining with neuroendocrine markers is essential in the diagnosis of neuroendocrine neoplasms of the esophagogastric junction

Introduction: Neuroendocrine neoplasms (NENs) of the esophagogastric junction (EGJ) are uncommon and the classification of these tumors has been revised several times. Since 2016, at the Department of Pathology, Rigshospitalet, Denmark, all adenocarcinomas (ACs) and poorly differentiated carcinomas of the EGJ have been stained routinely with the neuroendocrine markers, Synaptophysin and Chromogranin A, in order to detect a possible neuroendocrine component.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Jepsen D

Authors: Jepsen D, Fiehn A, Garbyal R, Engel U, Holm J,

Keywords: neuroendocrine neoplasm, neuroendocrine carcinoma, mixed neuroendocrine non-neuroendocrine neoplasm, esophagogastric junction, Synaptophysin, Chromogranin A,

#1490 Even Malignant Appendiceal Neuroendocrine Tumors Exhibit No Recurrent Chromosomal Alterations

Introduction: Neuroendocrine tumors (NETs) of the midgut are located in the ileum (iNET), caecum or appendix (aNET). Despite of the similar origin, NETs of the ileum and the appendix behave remarkably different. iNETs show high malignant potential, which manifests with early lymph node or liver metastases. Genetically, the loss of chromosome 18 (Ch18) in 60-74% of cases is the most frequent alteration in iNETs. aNETs are often incidental findings, rarely show metastases, and no chromosomal alterations are known.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Sipos B

Authors: Nann D, Nieser M, Sperveslage J, Henopp T, Vokuhl C,

Keywords: NET,