Molecular analysis of non-functioning PanNETs of the alpha lineage reveals new subtypes and mechanisms of progression

#4502

Introduction: Most pancreatic neuroendocrine tumours (PanNETs) are non-functioning. Previously, we demonstrated that small, MEN1-only mutated α-like PanNETs can be distinguished from larger ADM (mutated in ATRX, DAXX and MEN1) PanNETs based on epigenetic profiles. ADM PanNETs have shorter disease-free survival and a higher relapse risk. However, their therapeutic responses vary, underscoring group heterogeneity. ADM PanNETs remain insufficiently characterised, with potential subtype-specific progression drivers with implications for treatment choice and clinical outcome.

Aim(s): Identify specific mechanisms of progression by characterizing methylome and transcriptome of NF α-line PanNETs.

Materials and methods: We have analysed 139 epigenetic and 60 transcriptomic PanNET profiles, including 26 and 18 paired primary tumours and metastases.

Conference:

Presenting Author: Avanthay S

Authors: Avanthay S, Di Domenico A, Kirchner P, Bräutigam K, Chouchane A,

Keywords: pancreas, epigenetics, progression, metastasis, DAXX, ATRX, Pan NET,