Abstract Library

#3805 Transcriptomic analyses of multifocal ileal neuroendocrine tumors

Introduction: Small intestinal neuroendocrine tumors are mostly located in the distal ileum with a high incidence of multiple synchronous primary tumors. To date, loss of heterozygosity (LOH) at chr18 has been the most frequent genomic event identified, occurring in ~60% of tumors. Recently, we showed that synchronous primary tumors from the same ileal NET patient display distinct somatic mutational profiles, including distinct patterns of chr18 LOH, suggesting these tumors originate independently. Thus, new mechanistic insights into multifocal ileal NETs are urgently needed.

Conference:

Presenting Author:

Authors: Mäkinen N, Zhang Z, Munn S, Kasai Y, Kim G,

Keywords: Multifocal ileal NETs, RNA-sequencing, Gene expression,

#730 Loss of Chromosome 18 in Neuroendocrine Tumors of the Midgut

Introduction: The genetic alterations in neuroendocrine tumors (NET) of the midgut, in particular of the appendix (aNET), are poorly characterized. The most frequent chromosomal aberration in ileal NET (iNET) is the loss of one chromosome 18. The relevance of this alteration is unclear.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Henopp T, Brix J, Sperveslage J, Anlauf M, Petersen K,

Keywords: chr18,

#700 Comparative Expression Analysis of Chromosome 18 Related miRNAs in Ileal NET with and without Chr18 Loss

Introduction: MicroRNAs (miRs) play important roles in many kinds of biological processes. Because the (partial) loss of one chromosome 18 (Chr18) is a frequent event in ileal NETs (iNETs), we assessed the potential deregulation of miR-expression in these patients.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Sperveslage J

Authors: Hoffmeister M, Sperveslage J, Henopp T, Anlauf M, Petersen K,

Keywords: NET, mir-expression,