Abstract Library

#4531 The role of metabolism in neuroendocrine tumour cell models and patients

Introduction: It is recognised that the adipose tissue plays a major role in cancer through a metabolic coupling that supports tumour cell growth. Recent evidence suggests that altered metabolic pathways drive the development and influence the clinical outcomes of gastroenteropancreatic neuroendocrine tumours (GEP-NETs).

Conference:

Presenting Author: Calabrese C

Authors: Calabrese C, Dellavalle S, Miserocchi G, Gabellone S, Spadazzi C,

Keywords: tumour metabolism, adipocytes, RNA-sequencing, GEP-NET,

#4103 The evolutionary history of metastatic pancreatic neuroendocrine tumors reveals a therapy driven route to high-grade transformation

Introduction: Tumor evolution with acquisition of more aggressive disease characteristics is a hallmark of disseminated cancer. Metastatic pancreatic neuroendocrine tumors (PanNETs) in particular, show frequent progression from a low/intermediate to a high-grade disease.

Conference:

Presenting Author: Crona J

Authors: Backman S, Botling J, Nord H, Ghosal S, Stålberg P,

Keywords: Pancreatic neuroendocrine tumor, Tumor evolution, Alkylating chemotherapy, Treatment resistance,

#4068 YAP-1 as prognostic marker for immunochemotherapy response in SCLC patients

Introduction: Small-cell lung cancer (SCLC) represents about 15% of all lung cancers and is an exceptionally lethal malignancy for which more effective therapies are urgently needed. Previous studies have classified SCLC patients by RNA-sequencing (RNA-seq) clustering analysis to identify who could benefit from immune checkpoint blockades.

Conference:

Presenting Author:

Authors: Sabella G,

Keywords: neuroendocrine, immunochemotherapy, SCLC, YAP-1,

#4047 The role of adipocytes in neuroendocrine neoplasms: Molecular and metabolic adaptations

Introduction: It is recognized that the adipose tissue plays a major role in cancer. Recent evidence suggests the existence of altered metabolic pathways in neuroendocrine neoplasms (NENs), influencing tumor development and evolution, and thereby clinical outcomes.

Conference:

Presenting Author: Calabrese C

Authors: Calabrese C, Dellavalle S, Miserocchi G, Gabellone S, Spadazzi C,

Keywords: neuroendocrine neoplasm, adipocytes, metabolism, RNA-seq, 3D co-cultures,

#3935 Single-cell sequencing reveals the heterogeneity of pancreatic neuroendocrine tumors under the pattern of genomic instability and histological grading

Introduction: Non-functional pancreatic neuroendocrine tumor (NF-Pan-NET) is a kind of highly heterogeneous tumors. Histological grading is the key factors affecting the prognosis of patients and instructive in guiding treatment and assessing recurrence in NF-Pan-NET. 90% of NF-Pan-NET are grade G1 or G2, leading to an unpredictable clinical course that varies from indolent to highly malignant. Approximately one-third of patients without CNV alteration and the prognosis of these patients are better than that of patients with CNV alteration. Therefore, probing the heterogeneity of tumors based on histological grading and CNV variation is crucial.

Conference:

Presenting Author: Ye Z

Authors: Ye Z, Zhou C, Xu X, Chen J, Yu X,

Keywords: Pancreatic neuroendocrine tumor, single-cell sequencing, genomic instability, histological grading,