Abstract Library

#4558 Prognostic impact of primary tumour location after resection of neuroendocrine liver metastases from gastroenteropancreatic tumours

Introduction: Little evidence however exists regarding the prognostic impact of localisation of the primary tumour in case of neuroendocrine liver metastasis (NELM).

Conference:

Presenting Author: Coppa J

Authors: Simonotti N, Coppa J, Maspero M, Paoletti M, Pezzoli I,

Keywords: neuroendocrine liver metastasis, liver resection, hepatic surgery, pancreatic net, gastroenteropancreatic neuroendocrine tumour,

#4229 Bone health in neuroendocrine neoplasms

Introduction: Neuroendocrine neoplasms (NENs) are a heterogeneous group of rare neoplasms, classified according to localization of the primary tumor, differentiation and grading. The effect of localized or advanced NENs and systemic therapies on bone and muscle health is still controversial.

Conference:

Presenting Author:

Authors: Casabella A, Veresani A, Boschetti M, Sulli A, Hasballa I,

Keywords: Bone health, neuroendocrine neoplasm, TBS, RSMI, T-Score,

#4070 Ordinary colorectal cancers expressing synaptophysin: Myth or reality?

Introduction: Despite the neuroendocrine differentiation in CRCs has been extensively assessed, currently there are no established criteria for inclusion for this designation.

Conference:

Presenting Author:

Authors: Sabella G,

Keywords: neuroendocrine, MANEC, synapthophysin,

#4068 YAP-1 as prognostic marker for immunochemotherapy response in SCLC patients

Introduction: Small-cell lung cancer (SCLC) represents about 15% of all lung cancers and is an exceptionally lethal malignancy for which more effective therapies are urgently needed. Previous studies have classified SCLC patients by RNA-sequencing (RNA-seq) clustering analysis to identify who could benefit from immune checkpoint blockades.

Conference:

Presenting Author:

Authors: Sabella G,

Keywords: neuroendocrine, immunochemotherapy, SCLC, YAP-1,

#3910 Integrative molecular analysis of lung neuroendocrine neoplasms with different Ki-67 indices identifies a molecular transition group between low- and high-grade neoplasms

Introduction: In the 2021 World Health Organization (WHO) classification of lung cancers, lung neuroendocrine neoplasms (LNENs) are classified as low-grade, intermediate-grade and high-grade based on mitotic count but not Ki-67 index, as for GEP-NENs.

Conference:

Presenting Author:

Authors: Simbolo M, Centonze G, Ali G, Grillo F, Sabella G,

Keywords: lung neuroendocrine tumor, NET grade 3, next generation sequencing, transcriptomics,